MAST2 - microtubule associated serine/threonine kinase 2 Gene

Also Known as MTSSK; MAST205

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23139

About MAST2

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:45,803,612-46,036,122 (from NCBI)

This gene has 10 transcripts (splice variants), 227 orthologues and 13 paralogues. Broad expression in testis (RPKM 25.4), heart (RPKM 11.8) and 23 other tissues.

Summary

Enables Phosphatase binding activity. Predicted to be involved in several processes, including peptidyl-serine phosphorylation; regulation of interleukin-12 production; and spermatid differentiation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in microtubule Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

MAST2 Products (4)

mRNA	Protein	Name
NM_001319245.2	NP_001306174.1	microtubule-associated serine/threonine-protein kinase 2 isoform 2
NM_001324320.2	NP_001311249.1	microtubule-associated serine/threonine-protein kinase 2 isoform 3
NM_001324321.2	NP_001311250.1	microtubule-associated serine/threonine-protein kinase 2 isoform 4
NM_015112.3	NP_055927.2	microtubule-associated serine/threonine-protein kinase 2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables phosphatase binding	IPI IPI: Inferred from physical interaction	10646847	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12117771	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAST2 Protein Structure

DUF1908

Pkinase

PDZ

0
300
600
900
1200
1500
1798 a.a.

Protein Preferred Names	Protein Names
microtubule-associated serine/threonine-protein kinase 2	microtubule associated testis specific serine/threonine protein kinase

MAST2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	MAST2	Q6P0Q8	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	MAST2	Q6P0Q8	CDHR2	Homo sapiens	Q9BYE9	Imaging	12117771
Intra	MAST2	Q6P0Q8	CDHR2	Homo sapiens	Q9BYE9	CoIP	12117771
Intra	MAST2	Q6P0Q8	SLC9A3	Homo sapiens	P48764	Y2H	16159897
Intra	MAST2	Q6P0Q8	SLC9A3	Homo sapiens	P48764	Pull Down	16159897
Cross	MAST2	Q6P0Q8	SLC9A3	Didelphis virginiana	Q28362	Protein Kinase Assay	16159897

Cross: Cross-species interaction Intra: Intraspecies interaction

MAST2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P810975	MAST2 Antibody	WB, IHC-P, ICC/IF	Human, Mouse
HY-P89863	MAST205 Antibody (YA9207)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Mega-Corpus-Callosum Syndrome With Cerebellar Hypoplasia And Cortical Malformations	MCCCHCM
Inflammatory Bowel Disease 6	IBD6

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS08162	MAST2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MAST2	VGNC	VGNC:31258
Mus musculus	MAST2	MGD	MGI:894676
Macaca mulatta	MAST2	VGNC	VGNC:74532
Canis familiaris	MAST2	VGNC	VGNC:43033
Rattus norvegicus	MAST2	RGD	RGD:1304573
Felis catus	MAST2	VGNC	VGNC:80276
Others	MAST2	NCBI