Ripor2 - RHO family interacting cell polarization regulator 2 Gene

Also Known as Fam65b; Ab2-162; RGD1306939

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 306934

Summary

Predicted to enable 14-3-3 protein binding activity and identical protein binding activity. Predicted to be involved in several processes, including negative regulation of T cell activation; positive regulation of cellular component organization; and regulation of leukocyte migration. Located in apical plasma membrane and stereocilium membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 104. Orthologous to human RIPOR2 (RHO family interacting cell polarization regulator 2). [provided by Alliance of Genome Resources, Apr 2022]

Ripor2 Products (1)

mRNA Protein Name
NM_001014009.3 NP_001014031.2 rho family-interacting cell polarization regulator 2

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence Verweise Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
24958875 RGD
located in stereocilium IDA
IDA: Inferred from direct assay
24958875 RGD
located in stereocilium membrane IDA
IDA: Inferred from direct assay
24958875 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rho family-interacting cell polarization regulator 2

  • family with sequence similarity 65, member B

  • protein FAM65B

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-112038A GSK2983559 Inhibitor 99.49% Phase 1
HY-19764 GSK2983559 active metabolite Inhibitor 98.86% Phase 1
HY-112038 GSK2983559 free acid Inhibitor 99.49% Phase 1

Pre-clinical Phase

Bioactive Molecules (10)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-100339 GSK583 Inhibitor 99.93% Unkown
HY-N0600 Ginsenoside F3 99.84% Unkown
HY-111870 PROTAC RIPK degrader-6 Inhibitor 99.01% Unkown
HY-19761 RIP2 kinase inhibitor 2 Inhibitor 99.69% Unkown
HY-112907 RIP2 Kinase Inhibitor 3 Inhibitor 99.76% Unkown
HY-133014 RIP2 kinase inhibitor 1 Inhibitor / Unkown
HY-118316 GSK223 Inhibitor / Unkown
HY-136010 RIP2 Kinase Inhibitor 4 Inhibitor / Unkown
HY-147235 PROTAC RIPK2 Degrader-1 Inhibitor / Unkown
HY-RS12002 RIPOR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ripor2 NCBI NCBI:9750