MMP19 - matrix metallopeptidase 19 Gene

Also Known as CODA; MMP18; RASI-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4327

About MMP19

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,835,433-55,842,936 (from NCBI)

This gene has 9 transcripts (splice variants), 246 orthologues, 23 paralogues and is associated with 2 phenotypes. Broad expression in gall bladder (RPKM 58.3), appendix (RPKM 21.2) and 19 other tissues.

Summary

This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

MMP19 Products (3)

mRNA Protein Name
NM_001272101.2 NP_001259030.1 matrix metalloproteinase-19 isoform 3 preproprotein
NM_001414375.1 NP_001401304.1 matrix metalloproteinase-19 isoform 4 preproprotein
NM_002429.6 NP_002420.1 matrix metalloproteinase-19 isoform 1 preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables metalloendopeptidase activity EXP
EXP: Inferred from Experiment
10809722 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MMP19 Protein Structure

PG_binding_1

PG_binding_1: Putative peptidoglycan binding domain (30 - 80)

Peptidase_M10

Peptidase_M10: Matrixin (103 - 256)

Hemopexin

Hemopexin: Hemopexin (337 - 373)

Hemopexin

Hemopexin: Hemopexin (380 - 426)

Hemopexin

Hemopexin: Hemopexin (430 - 472)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
Protein Preferred Names Protein Names

matrix metalloproteinase-19

  • matrix metalloproteinase RASI

Recombinant MMP19 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P75929 MMP-19 Protein, Human (solution) Q99542-1 (L101-G256) ≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Cavitary Optic Disc Anomalies

  • Familial Cavitary Optic Disc Anomaly

  • CODA

  • Familial Coda
Suppurative Periapical Periodontitis

  • Periapical Abscess

  • Apical Abscess

  • Suppurative Apical Periodontitis

  • Dentoalveolar Abscess

  • Dental Abscess With Sinus

  • Dentoalveolar Abscess With Sinus

  • Dental Sinus

  • Periapical Abscess Fistula

  • Apical Tooth Abscess

  • Apex Abscess

  • Dental Abscess Nos

  • Infection Of Tooth Nos

  • Abscess Of Tooth

  • Dental Infection Nos
Arthritis

  • Inflammatory Joint Disease

  • Inflammatory Disorder Of Joint
Multiple Sclerosis

  • MS

  • Multiple Sclerosis, Susceptibility To

  • Disseminated Sclerosis

  • Multiple Sclerosis, Disease Progression, Modifier Of

  • Insular Sclerosis

  • Multiple Sclerosis Modifier Of Disease Progression

  • Multiple Sclerosis, Susceptibility To 1

  • Multiple Sclerosis, Susceptibility To, 1

  • Multiple Sclerosis 1

  • Generalized Multiple Sclerosis

  • Multiple Sclerosis Variant

  • Multiple Sclerosis Susceptibility To

  • Cerebrospinal Sclerosis

  • Generalised Multiple Sclerosis

  • Ms - [Multiple Sclerosis]

  • Disseminated Cerebrospinal Sclerosis

  • Disseminated Multiple Sclerosis

  • Disseminated Nervous System Myelosclerosis

  • Multiple Cerebrospinal Sclerosis

  • Multiple Combined Sclerosis

  • Multiple Sclerosis Generalised

  • Disseminated Brain Sclerosis

  • Disseminated Spinal Sclerosis

  • Insular Brain Sclerosis

  • Miliary Brain Sclerosis

  • Multiple Combined Sclerosis Of Spinal Cord

  • Multiple Ascending Sclerosis

  • Multiple Brain Sclerosis

  • Multiple Sclerosis Of Brain Stem

  • Multiple Sclerosis Of The Brain Stem

  • Multiple Sclerosis Of Cord

  • Sclérose En Plaques

  • Plaque Sclerosis

  • Multiple Sclerosis Of The Spinal Cord
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS08536 MMP19 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180115 Antibacterial agent 315 Inhibitor / Unkown
HY-RS20990 Mmp19 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27507 Mmp19 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MMP19 MGD MGI:1927899
Rattus norvegicus MMP19 RGD RGD:1311376
Bos taurus MMP19 VGNC VGNC:31523
Felis catus MMP19 VGNC VGNC:68286
Canis familiaris MMP19 VGNC VGNC:43279
Macaca mulatta MMP19 VGNC VGNC:74896
Others MMP19 NCBI