PLA2G4C - phospholipase A2 group IVC Gene

Also Known as CPLA2-gamma

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8605

About PLA2G4C

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,047,846-48,110,817 (from NCBI)

This gene has 24 transcripts (splice variants), 253 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 6.1), heart (RPKM 5.7) and 23 other tissues.

Summary

This gene encodes a protein which is a member of the Phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

PLA2G4C Products (3)

mRNA Protein Name
NM_001159322.2 NP_001152794.1 cytosolic phospholipase A2 gamma isoform 2 precursor
NM_001159323.2 NP_001152795.1 cytosolic phospholipase A2 gamma isoform 3
NM_003706.3 NP_003697.2 cytosolic phospholipase A2 gamma isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables O-acyltransferase activity IDA
IDA: Inferred from direct assay
15944408 GOA
enables calcium-independent phospholipase A2 activity IDA
IDA: Inferred from direct assay
10085124 GOA
enables lysophospholipase activity IDA
IDA: Inferred from direct assay
15944408 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in glycerophospholipid catabolic process IDA
IDA: Inferred from direct assay
10085124 GOA
involved in lipid droplet formation IMP
IMP: Inferred from mutant phenotype
28336330 GOA
involved in phosphatidylcholine acyl-chain remodeling IDA
IDA: Inferred from direct assay
19501189 GOA
involved in phosphatidylethanolamine acyl-chain remodeling IDA
IDA: Inferred from direct assay
19501189 GOA
involved in platelet activating factor biosynthetic process IDA
IDA: Inferred from direct assay
19501189 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
15944408 GOA
located in lipid droplet IDA
IDA: Inferred from direct assay
28336330 GOA
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
15944408 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLA2G4C Protein Structure

PLA2_B

PLA2_B: Lysophospholipase catalytic domain (44 - 242)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 541 a.a.
Protein Preferred Names Protein Names

cytosolic phospholipase A2 gamma

  • cytosolic lysophospholipase

Related Diseases

Diseases Alias
Pulmonary Systemic Sclerosis

  • Lung Disease With Systemic Sclerosis

  • Lung Involvement In Systemic Sclerosis
Autism Spectrum Disorder

  • Asd

  • Autism Spectrum Disorders

  • Autistic Continuum

  • Pervasive Developmental Disorder

  • Pervasive Development Disorder

  • Autistic Behavior

  • Autistic Disorder

  • Autistic

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Childhood Autism

  • Kanner Syndrome

  • Pervasive Developmental Delay Nos

  • Pervasive Developmental Disorder, Not Otherwise Specified
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10628 PLA2G4C Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PLA2G4C MGD MGI:1196403
Rattus norvegicus PLA2G4C RGD RGD:1594658
Others PLA2G4C NCBI