Sesquiterpene lactones from the roots of Ferula varia and their cytotoxic activity

  • J Nat Prod. 2007 Dec;70(12):1915-8. doi: 10.1021/np0703996.
Kyoko Suzuki  1 ,  Mamoru Okasaka ,  Yoshiki Kashiwada ,  Yoshihisa Takaishi ,  Gisho Honda ,  Michiho Ito ,  Yoshio Takeda ,  Olimjon K Kodzhimatov ,  Ozodbek Ashurmetov ,  Michiko Sekiya ,  Yasumasa Ikeshiro
Affiliations
  • 1. Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan.
PMID: 18052129 DOI: 10.1021/np0703996
Abstract

The ethyl acetate-soluble fraction from a MeOH extract of the roots of Ferula varia gave six new sesquiterpene lactones (1-6) and five known Sesquiterpenes (7-11). Their structures were established on the basis of spectroscopic evidence. The cytotoxic activities of 1-11 were evaluated against selected human Cancer cell lines. Compound 4 showed significant selective cytotoxicity against multidrug-resistant Cancer cells (KB-C2). The cytotoxicities of compounds 1, 3, 5, 8, and 11 against KB-C2 cells were enhanced in the presence of nontoxic concentrations of colchicine.