Cytotoxic flavanes from Uraria clarkei

  • J Asian Nat Prod Res. 2013 Sep;15(9):979-84. doi: 10.1080/10286020.2013.822368.
Zhi-Yong Jiang  1 ,  Xi-Shan Bai ,  Hui Liang ,  Chao Wang ,  Wen-Juan Li ,  Jun-Ming Guo ,  Xiang-Zhong Huang
Affiliations
  • 1. a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities , Kunming , 650500 , China.
PMID: 23909281 DOI: 10.1080/10286020.2013.822368
Abstract

Two new flavanes, (2R)-4'-hydroxy-2',5,7-trimethoxyflavane (1) and (2R,4R)-2',4'-dihydroxy-5,7-dimethoxyflavan-4-ol (2), were isolated from Uraria clarkei, together with two known compounds 5,7-dimethoxy-4'-hydroxyflavan (3) and 5,7,4'-trimethoxyflavan (4). The structures of the new flavanes were characterized by analyses of the MS, IR, UV, CD, 1D, and 2D NMR data. Cytotoxicity test suggested that compounds 1-4 possessed slight activity against K-562 and Hela cell lines, with the IC50 values ranging from 26.6 to 56.3 μM.

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