ADRA1A - adrenoceptor alpha 1A Gene

Also Known as ADRA1C; ADRA1L1; ALPHA1AAR

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 148

About ADRA1A

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:26,748,150-26,867,379 (from NCBI)

This gene has 11 transcripts (splice variants), 203 orthologues and 18 paralogues. Biased expression in fat (RPKM 3.7), liver (RPKM 3.6) and 6 other tissues.

Summary

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]

ADRA1A Products (7)

mRNA	Protein	Name
NM_000680.4	NP_000671.2	alpha-1A adrenergic receptor isoform 1
NM_001322502.1	NP_001309431.1	alpha-1A adrenergic receptor isoform 5
NM_001322503.1	NP_001309432.1	alpha-1A adrenergic receptor isoform 6
NM_001322504.1	NP_001309433.1	alpha-1A adrenergic receptor isoform 7
NM_033302.3	NP_150645.2	alpha-1A adrenergic receptor isoform 3
NM_033303.4	NP_150646.3	alpha-1A adrenergic receptor isoform 2
NM_033304.3	NP_150647.2	alpha-1A adrenergic receptor isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20508391	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	22120526	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	22120526	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	24567387	GOA
located in nuclear membrane	IDA IDA: Inferred from direct assay	22120526	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22120526	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24567387	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADRA1A Protein Structure

7tm_1

0
100
200
300
400
466 a.a.

Protein Preferred Names	Protein Names
alpha-1A adrenergic receptor	G protein coupled receptor

ADRA1A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82314	alpha 1a Adrenergic Receptor Antibody (YA2059)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P82314A	alpha 1a Adrenergic Receptor Antibody (YA2059)(PBS only)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Ureterolithiasis	Calculus Of Ureter Ureteric Stone Ureteral Calculi Ureteric Calculus Stone In The Ureter Ureter Calculi Ureteral Calculus Or Stone Ureterolith Ureterolithiasis Nos
Gilles De La Tourette Syndrome	Tourette Syndrome Tourette Disorder GTS Ts Gilles De La Tourette'S Syndrome Motor-Verbal Tic Disorder Guinon'S Disease Psychogenic Tics Tourette'S Syndrome Chronic Motor And Vocal Tic Disorder Td Tourette'S Disease Combined Vocal And Multiple Motor Tic Disorder [De La Tourette] Combined Vocal And Multiple Motor Tic Disorder Tic De La Tourette
Priapism	Mentulagra Priapism, Familial Idiopathic Familial Idiopathic Priapism Pathologic Erection Painful Erection
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Prostatic Hyperplasia, Benign	Benign Prostatic Hyperplasia BPH Prostatic Hyperplasia
Prostatitis
Prostatic Hypertrophy	Benign Prostatic Hypertrophy Prostatic Hyperplasia
Detrusor Sphincter Dyssynergia	Detrusor And Sphincter Dyssynergia
Situs Inversus	Situs Inversus Viscerum Laterality Sequence Complete Transposition Siv
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00408	ADRA1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00410	ADRA1D Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21088	Adra1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27606	Adra1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADRA1A	RGD	RGD:2055
Mus musculus	ADRA1A	MGD	MGI:104773
Macaca mulatta	ADRA1A	VGNC	VGNC:69721
Felis catus	ADRA1A	VGNC	VGNC:59654
Canis familiaris	ADRA1A	VGNC	VGNC:37672
Bos taurus	ADRA1A	VGNC	VGNC:25693
Others	ADRA1A	NCBI