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Cat. No.: HY-176805

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TGP-377

TGP-377 is a potent miR-377 inhibitor that specifically and effectively enhances VEGFA expression by targeting the non-coding microRNA that regulates VEGFA expression.

For research use only. We do not sell to patients.

CAS No.: 2665700-67-2
Formula: C₇₅H₉₃N₂₃O₇
Molecular Weight:1428.69

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

TGP-377 Chemical Structure

CAS No.: 2665700-67-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

TGP-377 is a potent miR-377 inhibitor that specifically and effectively enhances VEGFA expression by targeting the non-coding microRNA that regulates VEGFA expression^[1].

All VEGFR Isoforms :

Chemical Information

CAS No. 2665700-67-2
Molecular Weight 1428.69
Formula C₇₅H₉₃N₂₃O₇
SMILES

O=C(CN(CCCN1N=NC(CN2CCN(CC2)C3=CC(NC4=NC=CC(NC5=CC=C6C=CC=CC6=N5)=C4)=NC(C)=N3)=C1)C(CN(CCC)C(CN(CCC)C(CN(CCC)C(CN(CCC)C(CCCOC7=CC(C8=NC9=CC=C(C=C9N8)N)=CC(C%10=NC%11=C(N%10)C=C(N)C=C%11)=C7)=O)=O)=O)=O)=O)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Haniff HS, et al. Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold-small molecule interactions. Nat Chem. 2020 Oct;12(10):952-961. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Chemical Information
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TGP-377

All VEGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TGP-377 Related Classifications

HY-176805 Related Classifications