FOXJ1 - forkhead box J1 Gene

Also Known as HFH4; HFH-4; CILD43; FKHL13

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2302

About FOXJ1

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,136,333-76,141,245 (from NCBI)

This gene has 1 transcript (splice variant), 138 orthologues, 42 paralogues and is associated with 3 phenotypes. Biased expression in lung (RPKM 6.3), testis (RPKM 5.4) and 8 other tissues.

Summary

This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry. Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.[provided by RefSeq, Sep 2009]

FOXJ1 Products (1)

mRNA	Protein	Name
NM_001454.4	NP_001445.2	forkhead box protein J1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25609649	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	9096351	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in axoneme assembly	IMP IMP: Inferred from mutant phenotype	31630787	GOA
involved in ciliary basal body organization	IMP IMP: Inferred from mutant phenotype	31630787	GOA
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	31630787	GOA
involved in determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	31630787	GOA
involved in glomerular parietal epithelial cell development	IEP IEP: Inferred from expression pattern	9530170	GOA
involved in lung epithelium development	IEP IEP: Inferred from expression pattern	9530170	GOA
involved in metanephric part of ureteric bud development	IEP IEP: Inferred from expression pattern	9530170	GOA
involved in positive regulation of lung ciliated cell differentiation	IDA IDA: Inferred from direct assay	20539013	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9096351	GOA
involved in protein localization	IMP IMP: Inferred from mutant phenotype	31630787	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	17008636	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXJ1 Protein Structure

Forkhead

0
100
200
300
400
421 a.a.

Protein Preferred Names	Protein Names
forkhead box protein J1	fork head homologue 4

FOXJ1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FOXJ1	Q92949	RFX2	Homo sapiens	P48378	Anti Tag CoIP	28514442
Intra	FOXJ1	Q92949	RFX2	Homo sapiens	P48378	TAP	25609649
Intra	FOXJ1	Q92949	RFX2	Homo sapiens	P48378	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

FOXJ1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81362	FOXJ1 Antibody (YA1107)	IHC-P	Human
HY-P81362A	FOXJ1 Antibody (YA1107)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Ciliary Dyskinesia, Primary, 43	CILD43 Primary Ciliary Dyskinesia 43 Ciliary Dyskinesia, Primary, 43, With Or Without Situs Inversus Primary Ciliary Dyskinesia 43 With Or Without Situs Inversus Ciliary Dyskinesia, Primary, 43 With Or Without Situs Inversus
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary
Obstructive Hydrocephalus
Rhinitis	Runny Nose
Allergic Rhinitis	Hay Fever Allergic Rhinitis, Susceptibility To ALRH Atopic Rhinitis Seasonal Allergic Rhinitis Non-Seasonal Allergic Rhinitis Perenial Allergic Rhinitis Pollenosis Rhinitis Allergic Seasonal Rhinitis, Allergic, Perennial Allergic Rhinitis, Cause Unspecified Pollinosis Pollen Allergy Allergy Nos Due To Pollen Summer Catarrh Other Seasonal Allergic Rhinitis
Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive Hydrocephalus, X-Linked Hydrocephalus Adverse Event Hydrocephaly Nos
Joubert Syndrome 8	JBTS8 Joubert Syndrome, Type 8
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Situs Inversus	Situs Inversus Viscerum Laterality Sequence Complete Transposition Siv
Pleuropneumonia
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Pulmonary Immaturity	Primary Atelectasis Of Newborn Primary Atelectasis, In Perinatal Period Primary Failure To Expand Terminal Respiratory Units Immature Lungs Primary Atelectasis Pulmonary Immaturity Nos Lung Lobe Hypoplasia, Associated With Short Gestation Lung Nonexpansion Premature Lungs Pulmonary Hypoplasia Associated With Short Gestation Failure Of Expansion Of Terminal Respiratory Units Primary Atelectasis Of Fetus Or Newborn Primary Atelectasis In Perinatal Period
Cerebral Degeneration	Brain Degeneration Degenerative Brain Disorder
Kartagener Syndrome	Kartagener'S Syndrome
Visceral Heterotaxy	Situs Ambiguus Heterotaxia Heterotaxy Syndrome Heterotaxy Lateralization Defect Situs Ambiguous Left Isomerism Htx Ivemark Syndrome Right Isomerism Situs Ambiguus Viscerum Incomplete Situs Inversus Partial Situs Inversus Heterotaxy, Visceral Asplenia Syndrome Bilateral Left-Sidedness Polysplenia Syndrome Moller Syndrome
Meckel Syndrome, Type 1	Meckel-Gruber Syndrome Meckel Syndrome Dysencephalia Splanchnocystica Meckel Syndrome 1 MKS1 Mks Gruber Syndrome Meckel-Gruber Syndrome, Type 1 Mes Dysencephalia Splachnocystica Meckel Gruber Syndrome Meckel Syndrome Type 1
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163982	FOXJ1 agonist 1	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FOXJ1	VGNC	VGNC:72701
Canis familiaris	FOXJ1	VGNC	VGNC:40954
Felis catus	FOXJ1	VGNC	VGNC:62336
Bos taurus	FOXJ1	VGNC	VGNC:29089
Mus musculus	FOXJ1	MGD	MGI:1347474
Rattus norvegicus	FOXJ1	RGD	RGD:621764
Others	FOXJ1	NCBI