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FOXJ1 Antibody (YA1107)(PBS only)

(Synonyms: HFH4; HFH-4; FKHL13)

FOXJ1 Antibody (YA1107) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXJ1.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    IHC-P

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • FOXJ1 Antibody (YA1107)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:1000-1:2000

Product Details

Description

FOXJ1 Antibody (YA1107) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXJ1.

  • Host Rabbit
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 50 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 46 kDa
Immunogen

Recombinant protein of human FOXJ1

Purification

Affinity Purified

Conjugation

Non-conjugated

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    FOXJ1, which is a forkhead transcription factor, has been previously studied mostly as a ciliary transcription factor. FOXJ1 is essential in multiple physiological processes, especially ciliogenesis, embryonic development, and spontaneous autoimmunity inhibition. FOXJ1 also plays a role in malignancy. FOXJ1 is reduced or hypermethylated in gastric cancer, ovarian cancer, breast cancer, aggressive ependymoma, and choroid plexus tumors, and its decreased expression is associated with poor prognosis, indicating its role as a novel tumor suppressor. However, in hepatocellular carcinoma and clear-cell renal cell carcinoma, FOXJ1 is overexpressed and the expression levels correlate with poor prognosis[1].

  • Subcellular Localization

    Nucleus

  • Expression


    Tissue_specificity:Testis, oviduct, lung and brain cortex

  • SwissProt ID

    Q92949

  • Gene ID
    2302 [NCBI]
  • Synonyms

    HFH4; HFH-4; FKHL13

  • Research Field

    Epigenetics and Nuclear Signaling

References

[1]. Liu K, F, et al. Forkhead Box Protein J1 (FOXJ1) is Overexpressed in Colorectal Cancer and Promotes Nuclear Translocation of β-Catenin in SW620 Cells. Med Sci Monit. 2017 Feb 17;23:856-866. [Content Brief]

FOXJ1 Antibody (YA1107)(PBS only) Related Classifications

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Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • FOXJ1 Antibody (YA1107)(PBS only) Product Image