ATP2B4 - ATPase plasma membrane Ca2+ transporting 4 Gene

Also Known as MXRA1; PMCA4; ATP2B2; PMCA4b; PMCA4x

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 493

About ATP2B4

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:203,626,832-203,744,081 (from NCBI)

This gene has 7 transcripts (splice variants), 219 orthologues and 21 paralogues. Ubiquitous expression in endometrium (RPKM 66.6), fat (RPKM 45.1) and 23 other tissues.

Summary

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These Enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these Enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

ATP2B4 Products (8)

mRNA	Protein	Name
NM_001365783.2	NP_001352712.1	plasma membrane calcium-transporting ATPase 4 isoform 4c
NM_001365784.2	NP_001352713.1	plasma membrane calcium-transporting ATPase 4 isoform 4c
NM_001684.5	NP_001675.3	plasma membrane calcium-transporting ATPase 4 isoform 4b
NM_001001396.3	NP_001001396.1	plasma membrane calcium-transporting ATPase 4 isoform 4a
NM_001001396.3	NP_001001396.1	plasma membrane calcium-transporting ATPase 4 isoform 4a
NM_001365783.2	NP_001352712.1	plasma membrane calcium-transporting ATPase 4 isoform 4c
NM_001365784.2	NP_001352713.1	plasma membrane calcium-transporting ATPase 4 isoform 4c
NM_001684.5	NP_001675.3	plasma membrane calcium-transporting ATPase 4 isoform 4b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables P-type calcium transporter activity	IMP IMP: Inferred from mutant phenotype	8530416	GOA
enables calcium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	23549614	GOA
enables calmodulin binding	IDA IDA: Inferred from direct assay	8530416	GOA
enables nitric-oxide synthase binding	IPI IPI: Inferred from physical interaction	11591728	GOA
enables nitric-oxide synthase inhibitor activity	IDA IDA: Inferred from direct assay	11591728	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11274188	GOA
enables protein phosphatase 2B binding	IDA IDA: Inferred from direct assay	19287093	GOA
enables protein phosphatase 2B binding	IMP IMP: Inferred from mutant phenotype	25147342	GOA
enables protein phosphatase 2B binding	IPI IPI: Inferred from physical interaction	15955804	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in calcium ion export	IDA IDA: Inferred from direct assay	25798335	GOA
involved in calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	8530416	GOA
involved in cellular response to epinephrine stimulus	IDA IDA: Inferred from direct assay	19278978	GOA
involved in intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	19278978	GOA
involved in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	IDA IDA: Inferred from direct assay	17242280	GOA
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	25147342	GOA
involved in negative regulation of arginine catabolic process	IDA IDA: Inferred from direct assay	19278978	GOA
involved in negative regulation of blood vessel endothelial cell migration	IDA IDA: Inferred from direct assay	25147342	GOA
involved in negative regulation of calcineurin-NFAT signaling cascade	IDA IDA: Inferred from direct assay	19287093	GOA
involved in negative regulation of calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	15955804	GOA
involved in negative regulation of cardiac muscle hypertrophy in response to stress	IMP IMP: Inferred from mutant phenotype	19287093	GOA
involved in negative regulation of cellular response to vascular endothelial growth factor stimulus	IDA IDA: Inferred from direct assay	25147342	GOA
involved in negative regulation of citrulline biosynthetic process	IDA IDA: Inferred from direct assay	19278978	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	25147342	GOA
involved in negative regulation of nitric oxide biosynthetic process	IDA IDA: Inferred from direct assay	11591728	GOA
involved in negative regulation of nitric-oxide synthase activity	IDA IDA: Inferred from direct assay	11591728	GOA
involved in negative regulation of the force of heart contraction	IDA IDA: Inferred from direct assay	17242280	GOA
acts upstream of negative effect nitric oxide-cGMP-mediated signaling	IDA IDA: Inferred from direct assay	19278978	GOA
involved in positive regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	15955804	GOA
involved in regulation of cell cycle G1/S phase transition	IMP IMP: Inferred from mutant phenotype	24448801	GOA
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19287093	GOA
involved in response to hydrostatic pressure	IMP IMP: Inferred from mutant phenotype	19287093	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in T-tubule	IDA IDA: Inferred from direct assay	19287093	GOA
located in Z disc	IDA IDA: Inferred from direct assay	19287093	GOA
located in membrane	IDA IDA: Inferred from direct assay	8530416	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	23549614	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP2B4 Protein Structure

ATPase-IIB_Ca

ATP_Ca_trans_C

0
200
400
600
800
1000
1205 a.a.

Protein Preferred Names	Protein Names
plasma membrane calcium-transporting ATPase 4	ATPase, Ca++ transporting, plasma membrane 4

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Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01197	ATP2B4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20525	Atp2b4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27034	Atp2b4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ATP2B4	MGD	MGI:88111
Macaca mulatta	ATP2B4	VGNC	VGNC:70183
Bos taurus	ATP2B4	VGNC	VGNC:97243
Felis catus	ATP2B4	VGNC	VGNC:68639
Rattus norvegicus	ATP2B4	RGD	RGD:621305
Canis familiaris	ATP2B4	VGNC	VGNC:38259
Others	ATP2B4	NCBI