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LHX2 - LIM homeobox 2 Gene

Also Known as LH2; hLhx2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9355

About LHX2

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:124,011,768-124,033,301 (from NCBI)

This gene has 4 transcripts (splice variants), 222 orthologues and 20 paralogues. Biased expression in brain (RPKM 8.5), placenta (RPKM 1.0) and 2 other tissues.

Summary

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution. [provided by RefSeq, Jul 2008]

LHX2 Products (1)

mRNA	Protein	Name
NM_004789.4	NP_004780.3	LIM/homeobox protein Lhx2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20211142	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LHX2 Protein Structure

LIM

Homeobox

0
100
200
300
406 a.a.

Protein Preferred Names	Protein Names
LIM/homeobox protein Lhx2	LIM HOX gene 2

LHX2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LHX2	P50458	LGALSL	Homo sapiens	Q3ZCW2	Validated Y2H	32296183
Intra	LHX2	P50458	ZNF511	Homo sapiens	Q8NB15	Validated Y2H	32296183
Intra	LHX2	P50458	MORF4L1	Homo sapiens	Q9UBU8-2	Validated Y2H	32296183
Intra	LHX2	P50458	TRAPPC2L	Homo sapiens	Q9UL33-2	Validated Y2H	32296183
Intra	LHX2	P50458	TRAPPC2L	Homo sapiens	Q9UL33-2	Y2H Array	32296183
Intra	LHX2	P50458	ANKS1A	Homo sapiens	Q49AR9	Validated Y2H	32296183
Intra	LHX2	P50458	TCEANC	Homo sapiens	Q8N8B7-2	Validated Y2H	32296183
Intra	LHX2	P50458	LDB1	Homo sapiens	Q86U70-2	Validated Y2H	32296183
Intra	LHX2	P50458	ZFP42	Homo sapiens	Q96MM3	Validated Y2H	32296183
Intra	LHX2	P50458	POU4F2	Homo sapiens	Q12837	Validated Y2H	32296183
Intra	LHX2	P50458	LONRF1	Homo sapiens	Q17RB8	Validated Y2H	32296183
Intra	LHX2	P50458	TCP11L1	Homo sapiens	Q9NUJ3	Validated Y2H	32296183
Intra	LHX2	P50458	PPIL1	Homo sapiens	Q9Y3C6	Validated Y2H	32296183
Intra	LHX2	P50458	OSMR	Homo sapiens	Q99650	Validated Y2H	32296183
Intra	LHX2	P50458	LDB1	Homo sapiens	Q86U70	Affinity Chrom	35140242
Intra	LHX2	P50458	LDB1	Homo sapiens	Q86U70	BioID	35140242
Intra	LHX2	P50458	FLYWCH1	Homo sapiens	Q4VC44	Validated Y2H	32296183
Intra	LHX2	P50458	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	32296183
Intra	LHX2	P50458	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	LHX2	P50458	TLK1	Homo sapiens	Q9UKI8	Validated Y2H	32296183
Intra	LHX2	P50458	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	32296183
Intra	LHX2	P50458	BEND2	Homo sapiens	Q8NDZ0	Validated Y2H	32296183
Intra	LHX2	P50458	MORN3	Homo sapiens	Q6PF18	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

LHX2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82228	LHX2 Antibody (YA1973)	WB	Human, Mouse, Rat
HY-P85257	LHX2 Antibody (YA4949)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Aniridia 1	Aniridia Congenital Aniridia AN1 An Cataract With Late-Onset Corneal Dystrophy Aplasia Of Iris Absent Iris Irideremia Aniridia Ii, Formerly An2, Formerly An2 Aniridia Type Ii Aniridia, Type 1 An-1 Absence Of Iris Agenesis Of Iris Congenital Absence Of Iris Hereditary Aniridia Sporadic Aniridia
Coloboma Of Macula	Coloboma Congenital Ocular Coloboma Microphthalmia, Isolated, With Coloboma Agenesis Of Macula Hereditary Macular Coloboma Ocular Coloboma Coloboma Of Eye Macular Coloboma Uveoretinal Coloboma
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Leber Plus Disease	Leber Congenital Amaurosis Lca Leber'S Amaurosis Leber'S Disease Amaurosis Congenita Of Leber Amaurosis Congenita Of Leber, Type 1 Lhon Plus Disease Congenital Absence Of The Rods And Cones Congenital Retinal Blindness Crb Congenital Amaurosis Of Retinal Origin Leber'S Congenital Amaurosis Leber Congenital Amaurosis 1 Leber'S Congenital Tapetoretinal Degeneration Leber'S Congenital Tapetoretinal Dysplasia Lca1 Leber Congenital Amaurosis Type 1 Retinal Blindness, Congenital Amaurosis, Leber Congenital Dysgenesis Neuroepithelialis Retinae Hereditary Epithelial Dysplasia Of Retina Hereditary Retinal Aplasia Heredoretinopathia Congenitalis Leber Abiotrophy Leber Congenital Tapetoretinal Degeneration Lebers Congenital Amaurosis Optic Atrophy, Hereditary, Leber
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07632	LHX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21366	Lhx2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27885	Lhx2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LHX2	RGD	RGD:71076
Felis catus	LHX2	VGNC	VGNC:102947
Macaca mulatta	LHX2	VGNC	VGNC:74262
Mus musculus	LHX2	MGD	MGI:96785
Canis familiaris	LHX2	VGNC	VGNC:42663
Bos taurus	LHX2	VGNC	VGNC:30872
Others	LHX2	NCBI