FLYWCH1 - FLYWCH-type zinc finger 1 Gene
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 84256
Summary
Enables transcription coactivator binding activity and transcription corepressor activity. Involved in DNA damage response and negative regulation of transcription by RNA polymerase II. Located in nuclear body and pericentric heterochromatin. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Jun 2026]
Ubiquitous expression in spleen (RPKM 6.6), ovary (RPKM 5.2) and 25 other tissues.
FLYWCH1 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001308068.2 | NP_001294997.1 | FLYWCH-type zinc finger-containing protein 1 isoform c |
| NM_020912.2 | NP_065963.1 | FLYWCH-type zinc finger-containing protein 1 isoform b |
| NM_032296.3 | NP_115672.2 | FLYWCH-type zinc finger-containing protein 1 isoform a |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| enables transcription coactivator binding |
IPI
IPI: Inferred from physical interaction
|
30097457 | GOA |
| enables transcription corepressor activity |
IDA
IDA: Inferred from direct assay
|
30097457 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in DNA damage response |
IMP
IMP: Inferred from mutant phenotype
|
33924684 | GOA |
| involved in negative regulation of transcription by RNA polymerase II |
IMP
IMP: Inferred from mutant phenotype
|
30097457 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in nuclear body |
IDA
IDA: Inferred from direct assay
|
33924684 | GOA |
| located in pericentric heterochromatin |
IDA
IDA: Inferred from direct assay
|
34408139 | GOA |
| part of transcription regulator complex |
IMP
IMP: Inferred from mutant phenotype
|
30097457 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
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FLYWCH1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
FLYWCH1 | Q4VC44 | PPP1R16B | Homo sapiens | Q96T49 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | PPP1R16B | Homo sapiens | Q96T49 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | PPP1R16B | Homo sapiens | Q96T49 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | HOOK2 | Homo sapiens | Q96ED9-2 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | HOOK2 | Homo sapiens | Q96ED9-2 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | HOOK2 | Homo sapiens | Q96ED9-2 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | MTUS2 | Homo sapiens | Q5JR59-3 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | MTUS2 | Homo sapiens | Q5JR59-3 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | MTUS2 | Homo sapiens | Q5JR59-3 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | CCDC125 | Homo sapiens | Q86Z20 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | CCDC125 | Homo sapiens | Q86Z20 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | CCDC125 | Homo sapiens | Q86Z20 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | LHX2 | Homo sapiens | P50458 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | LHX2 | Homo sapiens | P50458 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | KIFC3 | Homo sapiens | Q9BVG8-5 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | KIFC3 | Homo sapiens | Q9BVG8-5 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | KIFC3 | Homo sapiens | Q9BVG8-5 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | GMCL1 | Homo sapiens | Q96IK5 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | GMCL1 | Homo sapiens | Q96IK5 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | GMCL1 | Homo sapiens | Q96IK5 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | TRAF2 | Homo sapiens | Q12933 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | TRAF2 | Homo sapiens | Q12933 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | GOLGA6L9 | Homo sapiens | A6NEM1 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | GOLGA6L9 | Homo sapiens | A6NEM1 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | HSF2BP | Homo sapiens | O75031 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | HSF2BP | Homo sapiens | O75031 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | PICK1 | Homo sapiens | Q9NRD5 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | PICK1 | Homo sapiens | Q9NRD5 | 32296183 | |
|
Intra
|
FLYWCH1 | Q4VC44 | PICK1 | Homo sapiens | Q9NRD5 | 32296183 |
Cross: Cross-species interaction
Intra: Intraspecies interaction