Melrilimab
Based on 1 Customer Validation
Melrilimab (GSK 3772847; CNTO-7160) is a humanized IgG2σ monoclonal antibody that targets the IL-33 receptor ST2 and blocks the IL-33/ST2 signaling pathway by binding to the ST2 protein. Melrilimab is applicable to research related to asthma and atopic dermatitis.
For research use only. We do not sell to patients.
- Purity: 96.07%
- CAS No.: 2222865-46-3
- Molecular Weight:145.2 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human IgG2 kappa
Human
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ST2 |
Melrilimab effectively binds to its target in vivo, inhibits serum free sST2 and accumulates total sST2, but fails to significantly improve the clinical symptoms of asthma and atopic dermatitis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG2 kappa
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 2222865-46-3
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Appearance Liquid
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Molecular Weight 145.2 kDa
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Color Colorless to light yellow
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SMILES
[Melrilimab]
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Synonyms
GSK 3772847; CNTO-7160
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Sheng F, et al. IL-33/ST2 axis in diverse diseases: regulatory mechanisms and therapeutic potential. Frontiers in immunology. 2025;16:1533335. [Content Brief]
[2]. Timotievich ED, et al. Role of Cytokines IL-25, IL-33, and TSLP in the Respiratory Tract Inflammation: Therapeutic Perspectives. Biochemistry. Biokhimiia. 2026 Jan;91(1):17-38. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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