2222865-46-3
2222865-46-3
Chemical Structure
Melrilimab
Synonym(s): GSK 3772847; CNTO-7160
- CAS No.: 2222865-46-3
- Formula:N/A
- Molecular Weight:(145.2 kDa)
SMILES: [Melrilimab]
Biological Activity: Melrilimab (GSK 3772847; CNTO-7160) is a humanized IgG2σ monoclonal antibody that targets the IL-33 receptor ST2 and blocks the IL-33/ST2 signaling pathway by binding to the ST2 protein. Melrilimab is applicable to research related to asthma and atopic dermatitis[1][2].
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Melrilimab | 96.07% | Melrilimab (GSK 3772847; CNTO-7160) is a humanized IgG2σ monoclonal antibody that targets the IL-33 receptor ST2 and blocks the IL-33/ST2 signaling pathway by binding to the ST2 protein. Melrilimab is applicable to research related to asthma and atopic dermatitis. | ||||||||||||||||||||
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References
- [1]. Sheng F, et al. IL-33/ST2 axis in diverse diseases: regulatory mechanisms and therapeutic potential. Frontiers in immunology. 2025;16:1533335. [Content Brief]
- [2]. Timotievich ED, et al. Role of Cytokines IL-25, IL-33, and TSLP in the Respiratory Tract Inflammation: Therapeutic Perspectives. Biochemistry. Biokhimiia. 2026 Jan;91(1):17-38. [Content Brief]
