1. Neuronal Signaling
  2. Amyloid-β
  3. AZD4694

AZD4694 (Synonyms: NAV4694)

Cat. No.: HY-113938
Handling Instructions

AZD4694 (NAV4694), a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils (Kd = 2.3 nM).

For research use only. We do not sell to patients.

AZD4694 Chemical Structure

AZD4694 Chemical Structure

CAS No. : 1054629-49-0

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Description

AZD4694 (NAV4694), a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils (Kd = 2.3 nM)[1].

IC50 & Target

Kd: 2.3 nM (Aβ)

In Vivo

Administration of unlabeled AZD4694 to rat showed that it has a pharmacokinetic profile consistent with good PET radioligands, it quickly entered and rapidly cleared from normal rat brain tissue[1].
AZD4694 (4 mL/kg; intravenous injection) inhibits [3H]AZD2184 binding (1 nM) in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague–Dawley rats (275-300 g)[1]
Dosage: 4 mL/kg
Administration: I.v.
Result: Inhibited [3H]AZD2184 binding in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients.
Molecular Weight

258.25

Formula

C₁₄H₁₁FN₂O₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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AZD4694
Cat. No.:
HY-113938
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