2241039-81-4
2241039-81-4
Chemical Structure
Londamocitinib
Synonym(s): AZD4604; JAK1-IN-7
- CAS No.: 2241039-81-4
- Formula:C28H31F2N7O4S
- Molecular Weight:599.65
IUPAC Name: (R)-N-(3-(5-fluoro-2-((2-fluoro-3-(methylsulfonyl)phenyl)amino)pyrimidin-4-yl)-1H-indol-7-yl)-3-methoxy-2-(4-methylpiperazin-1-yl)propanamide
InChIKey: JNUZADQZHYFJGW-JOCHJYFZSA-N
SMILES: FC1=C(S(C)(=O)=O)C=CC=C1NC2=NC(C3=CNC4=C3C=CC=C4NC([C@@H](COC)N5CCN(C)CC5)=O)=C(F)C=N2
Biological Activity: Londamocitinib (AZD4604) is a potent and selective JAK1 inhibitor with IC50 at 0.54 nM. Londamocitinib has anti-inflammatory activity[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Londamocitinib | 99.79% | Londamocitinib (AZD4604) is a potent and selective JAK1 inhibitor with IC50 at 0.54 nM. Londamocitinib has anti-inflammatory activity. | ||||||||||||||||||||
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References
- [1]. NILSSON, Karl, Magnus, et al. Jak1 selective inhibitors. WO2018134213A1.
- [2]. Nilsson M, et al. Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization. J Med Chem. 2023 Oct 12;66(19):13400-13415. [Content Brief]
- [3]. Nilsson M, et al. Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma. Drug Des Devel Ther. 2022 Aug 31;16:2901-2917. [Content Brief]
Keywords
