WFDC2 - WAP four-disulfide core domain 2 Gene

Also Known as HE4; WAP5; EDDM4; dJ461P17.6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10406

About WFDC2

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,469,753-45,481,532 (from NCBI)

This gene has 7 transcripts (splice variants) and 100 orthologues. Biased expression in salivary gland (RPKM 317.9), endometrium (RPKM 117.3) and 8 other tissues.

Summary

This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]

WFDC2 Products (1)

mRNA Protein Name
NM_006103.4 NP_006094.3 WAP four-disulfide core domain protein 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25362534 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WFDC2 Protein Structure

WAP

WAP: WAP-type (Whey Acidic Protein) 'four-disulfide core' (32 - 73)

WAP

WAP: WAP-type (Whey Acidic Protein) 'four-disulfide core' (76 - 122)

  • 0
  • 100
  • 124 a.a.
Protein Preferred Names Protein Names

WAP four-disulfide core domain protein 2

  • WAP domain containing protein HE4-V4

WFDC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
WFDC2 Q14508 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
Intra
WFDC2 Q14508 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra
WFDC2 Q14508 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
WFDC2 Q14508 SLC22A23 Homo sapiens A1A5C7-2
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 SLC22A23 Homo sapiens A1A5C7-2
Y2H Array
32296183
Intra
WFDC2 Q14508 STOM Homo sapiens P27105
Y2H Array
32296183
Intra
WFDC2 Q14508 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
WFDC2 Q14508 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
WFDC2 Q14508 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
WFDC2 Q14508 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
WFDC2 Q14508 ANXA2 Homo sapiens P07355
Anti Bait CoIP
25362534
Intra
WFDC2 Q14508 ANXA2 Homo sapiens P07355
Anti Bait CoIP
31210752
Intra
WFDC2 Q14508 ANXA2 Homo sapiens P07355
IF
25362534
Intra
WFDC2 Q14508 GORAB Homo sapiens Q5T7V8
Y2H Array
32296183
Intra
WFDC2 Q14508 GORAB Homo sapiens Q5T7V8
Validated Y2H
32296183
Intra
WFDC2 Q14508 GORAB Homo sapiens Q5T7V8
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 FKBP7 Homo sapiens Q9Y680
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 FKBP7 Homo sapiens Q9Y680
Anti Tag CoIP
33961781
Intra
WFDC2 Q14508 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
Intra
WFDC2 Q14508 FKBP7 Homo sapiens Q9Y680
Y2H Array
32296183
Intra
WFDC2 Q14508 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
WFDC2 Q14508 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
WFDC2 Q14508 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
WFDC2 Q14508 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
WFDC2 Q14508 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 PANX1 Homo sapiens Q96RD7
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 PANX1 Homo sapiens Q96RD7
Validated Y2H
32296183
Intra
WFDC2 Q14508 PANX1 Homo sapiens Q96RD7
Y2H Array
32296183
Intra
WFDC2 Q14508 COQ9 Homo sapiens O75208
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 COQ9 Homo sapiens O75208
Y2H Array
32296183
Intra
WFDC2 Q14508 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
WFDC2 Q14508 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant WFDC2 Proteins

Cat. No. Product Name Accession Purity
HY-P71432 HE4/WFDC2 Protein, Human (HEK293, His) Q14508 (E31-F124) ≥ 95%, as determined by reducing SDS-PAGE.

WFDC2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81043 HE4 Antibody (YA889) WB, IHC-P, ICC/IF, IP, FC, IF-Tissue Human, Mouse

Related Diseases

Diseases Alias
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Malignant Ovarian Cyst
Ovarian Cyst

  • Ovarian Cysts
Mucinous Ovarian Cystadenoma

  • Mucinous Cystadenoma Of Ovary

  • Ovarian Mucinous Cystadenoma
Ovarian Mucinous Cystadenocarcinoma

  • Mucinous Cystadenocarcinoma Of Ovary
Ovarian Cystadenoma

  • Cystoma Serosum Simplex

  • Simple Cystoma Of Ovary

  • Simple Cystoma Of The Ovary
Endometrial Cancer

  • Endometrial Carcinoma

  • Endometrial Neoplasm

  • Malignant Neoplasm Of Endometrium

  • Endometrioid Carcinoma

  • Endometrial Neoplasms

  • Carcinoma, Endometrioid

  • Endometrial Cancer, Familial

  • Endometrial Carcinoma, Somatic

  • Endometrial Cancer, Susceptibility To

  • Endometrial Ca

  • Malignant Endometrial Neoplasm

  • Neoplasm Of Endometrium

  • Primary Malignant Neoplasm Of Endometrium

  • Tumor Of Endometrium

  • Carcinoma Of The Endometrium

  • Endometrioid Carcinoma Of Female Reproductive System

  • ENDMC

  • Carcinoma Endometrioid

  • Endometrial Cancers

  • Cancer, Endometrial

  • Uterine Corpus Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15811 WFDC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18304 Wfdc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24782 Wfdc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris WFDC2 VGNC VGNC:54267
Rattus norvegicus WFDC2 RGD RGD:628757
Macaca mulatta WFDC2 VGNC VGNC:78993
Mus musculus WFDC2 MGD MGI:1914951
Bos taurus WFDC2 VGNC VGNC:36933
Others WFDC2 NCBI