Amhr2 - anti-Mullerian hormone type 2 receptor Gene

Also Known as C14; Mrii; Misiir; Misrii

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110542

About Amhr2

Chromosome 15: 102,353,802-102,363,068 forward strand.GRCm39:CM001008.3

This gene has 5 transcripts (splice variants), 179 orthologues, 11 paralogues and is associated with 8 phenotypes. Biased expression in testis adult (RPKM 55.6) and ovary adult (RPKM 49.5).

Summary

Enables anti-Mullerian hormone receptor activity. Acts upstream of or within anti-Mullerian hormone signaling pathway; negative regulation of anti-Mullerian hormone signaling pathway; and sex differentiation. Predicted to be integral component of plasma membrane. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including early embryo; forebrain; genitourinary system; and nose. Used to study persistent Mullerian duct syndrome. Human ortholog(s) of this gene implicated in persistent Mullerian duct syndrome. Orthologous to human AMHR2 (anti-Mullerian hormone receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]

Amhr2 Products (2)

mRNA Protein Name
NM_144547.2 NP_653130.2 anti-Muellerian hormone type-2 receptor precursor
NM_001356575.1 NP_001343504.1 anti-Muellerian hormone type-2 receptor precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within sex differentiation IMP
IMP: Inferred from mutant phenotype
8895659 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Amhr2 Protein Structure

LU

LU: cl10471 (60 - 118)

PKc_like

PKc_like: cl21453 (202 - 503)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 568 a.a.
Protein Preferred Names Protein Names

anti-Muellerian hormone type-2 receptor

  • AMH type II receptor

  • MIS type II receptor

  • anti-Muellerian hormone type II receptor

  • anti-Mullerian hormone type 2 receptor delta 2

  • anti-Mullerian hormone type 2 receptor delta 9/10

Recombinant Amhr2 Proteins

Cat. No. Product Name Accession Purity
HY-P78693 AMHR2/MISRII Protein, Mouse (HEK293, His) Q8K592 (Q16-M147) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00654 AMHR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00655 Amhr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00656 Amhr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174780 Human AMHR2 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Amhr2 NCBI NCBI:269