AMHR2 - anti-Mullerian hormone receptor type 2 Gene

Homo sapiens

Also known as AMHR; MRII; MISR2; MISRII

Gene ID: 269 | Gene type: protein coding

About AMHR2

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,423,855-53,431,672 (from NCBI)

This gene has 7 transcripts (splice variants), 179 orthologues, 11 paralogues and is associated with 2 phenotypes. Biased expression in ovary (RPKM 12.2), adrenal (RPKM 9.0) and 3 other tissues.

Summary

This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009]

AMHR2 Products(17)

mRNA	Protein	Name
XM_011538173.2	XP_011536475.1	anti-Muellerian hormone type-2 receptor isoform X1
XM_011538176.2	XP_011536478.1	anti-Muellerian hormone type-2 receptor isoform X3
XM_011538180.2	XP_011536482.1	anti-Muellerian hormone type-2 receptor isoform X6
XM_011538185.2	XP_011536487.1	anti-Muellerian hormone type-2 receptor isoform X12
XM_011538174.2	XP_011536476.1	anti-Muellerian hormone type-2 receptor isoform X2
XM_047428700.1	XP_047284656.1	anti-Muellerian hormone type-2 receptor isoform X14
NM_001164690.2	NP_001158162.1	anti-Muellerian hormone type-2 receptor isoform 2 precursor
XM_011538184.2	XP_011536486.1	anti-Muellerian hormone type-2 receptor isoform X11
XM_017019179.2	XP_016874668.1	anti-Muellerian hormone type-2 receptor isoform X9
XM_011538179.2	XP_011536481.1	anti-Muellerian hormone type-2 receptor isoform X5
XM_011538183.2	XP_011536485.1	anti-Muellerian hormone type-2 receptor isoform X10
NM_020547.3	NP_065434.1	anti-Muellerian hormone type-2 receptor isoform 1 precursor
NM_001164691.2	NP_001158163.1	anti-Muellerian hormone type-2 receptor isoform 3 precursor
XM_024448938.2	XP_024304706.1	anti-Muellerian hormone type-2 receptor isoform X8
XM_011538181.2	XP_011536483.1	anti-Muellerian hormone type-2 receptor isoform X7
XM_011538178.2	XP_011536480.1	anti-Muellerian hormone type-2 receptor isoform X4
XM_011538186.4	XP_011536488.1	anti-Muellerian hormone type-2 receptor isoform X13

AMHR2 Protein Structure

Activin_recp

Pkinase

0
100
200
300
400
500
573 a.a.

Protein Preferred Names

Protein Names

anti-Muellerian hormone type-2 receptor

AMH type II receptor	MIS type II receptor
Muellerian inhibiting substance type II receptor	Mullerian inhibiting substance type II receptor
anti-Muellerian hormone type II receptor	anti-Mullerian hormone receptor, type II

Recombinant AMHR2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77870	AMHR2/MISRII Protein, Human (HEK293, Fc)	Q16671 (P18-S144)	≥95%
HY-P700953	AMHR2/MISRII Protein, Human (HEK293)	Q16671-1 (P18-S144)	≥95%

Related Diseases

Diseases

Alias

Herpangina

Vesicular Pharyngitis

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Persistent Mullerian Duct Syndrome, Types I And Ii

Persistent Mullerian Duct Syndrome, Type Ii	Persistent Mullerian Duct Syndrome, Type I
PMDS	Pseudohermaphroditism, Male Internal
Hernia Uteri Inguinale	Persistent Oviduct Syndrome
Female Genital Ducts In Otherwise Normal Male	Persistent Muellerian Duct Syndrome 1
PMDS1	Persistent Muellerian Duct Syndrome Type I
Pmds-1	Persistent Muellerian Duct Syndrome 2
PMDS2	Persistent Muellerian Duct Syndrome Type Ii
Pmds-2	Mullerian Duct Syndrome. Persistent, Types I And Ii

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism	Undescended Testicle
Undescended Testis	Cryptorchism
Undescended Testicles	CRYPTO
Impaired Testicular Descent	Cryptosporidiosis
Retained Testis	Unilateral Cryptorchidism
Unilateral Undescended Testis	Nondescent Unilateral Testicle
Unilateral Cryptorchism	Ectopic Testis, Unilateral
Bilateral Cryptorchidism	Bilateral Cryptorchism
Bilateral Nondescent Testicle	Bilateral Undescended Testes
Bilateral Ectopic Testes

West Nile Encephalitis

West-Nile Encephalitis	West Nile Fever
West Nile Fever Encephalitis	West Nile Fever With Encephalitis
West-Nile Fever	Encephalitis, West Nile Fever

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Epithelial Ovarian Cancer
Neoplasm Of Ovary	Ovarian Neoplasms
Ovarian Cancers	Malignant Neoplasm Of Ovary
Primary Malignant Neoplasm Of Ovary	Ovarian Cancer, Somatic
Malignant Ovarian Tumor	Ovary Neoplasm
Primary Ovarian Cancer	Tumor Of The Ovary
Cancer Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Luteoma

Leuteoma Of Pregnancy

Luteoma Of Pregnancy

46,Xy Sex Reversal

Swyer Syndrome	Pure Gonadal Dysgenesis 46,Xy
Gonadal Dysgenesis, Xy Female Type	Gonadal Dysgenesis, 46,Xy
46,Xy Cgd	46,Xy Complete Gonadal Dysgenesis
46,Xy Pure Gonadal Dysgenesis	46 Xy Gonadal Dysgenesis
46, Xy Cgd	46, Xy Complete Gonadal Dysgenesis
46, Xy Pure Gonadal Dysgenesis	Xy Pure Gonadal Dysgenesis
Female With 46,Xy Karyotype	Xy Females

Inguinal Hernia

Hernia Inguinal	Hernia, Inguinal
Inguinal Hernias	Bubonocele
Indirect Inguinal Hernia	Direct Inguinal Hernia
Oblique Inguinal Hernia	Scrotal Hernia
Ih - [Inguinal Hernia]

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Genetic Non-Acquired Premature Ovarian Failure

Pseudohermaphroditism

Indeterminate Sex And Pseudohermaphroditism

Testicular Disease

Testicular Dysfunction	Testicular Diseases
Disorder Of Testis	Testis Disorder
Testicular Disorders

Sex Cord-Gonadal Stromal Tumor

Sex Cord Stromal Tumour	Sex Cord-Gonadal Stromal Tumour
Sex Cord-Stromal Neoplasm	Specialized Gonadal Neoplasm
Specialized Gonadal Tumor	Specialized Gonadal Tumour
Sex Cord-Gonadal Stromal Tumors	Sex Cord-Stromal Tumor
Malignant Testicular Sex Cord-Stromal Tumor	Sex Cord Stromal Tumor Of Testis

Ovarian Disease

Ovarian Dysfunction	Ovarian Diseases
Ovarian Disorders	Disorder Of Endocrine Ovary

Hermaphroditism

Anovulation

Lipoid Congenital Adrenal Hyperplasia

Congenital Adrenal Hyperplasia	Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency
Congenital Lipoid Adrenal Hyperplasia	Lipoid Cah
Lipoid Adrenal Hyperplasia	Adrenal Hyperplasia 1
Cah	Clah
LCAH	Adrenal Hyperplasia I
Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism	Congenital Adrenal Hyperplasia Lipoid
Adrenal Hyperplasia, Congenital	Congenital Adrenal Hyperplasia, Lipoid
AH1	Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism
Adrenal Hyperplasia Congenital	Hyperplasia, Adrenal, Lipoid, Congenital
Congenital Adrenogenital Disorders Associated With Enzyme Deficiency	Congenital Adrenal Cortical Hyperplasia
Congenital Adrenal Gland Hyperplasia	Congenital Adrenogenital Syndrome
Congenital Hyperadrenocorticism	Congenital Adrenogenitalism
Congenital Female Adrenal Pseudohermaphroditism

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Salivary Gland Disease

Salivary Gland Disorders	Salivary Gland Diseases
Non-Neoplastic Salivary Gland Disease	Non-Neoplastic Salivary Gland Disorder
Disorder Of Salivary Gland	Lesion Of Salivary Gland Nos

Hypogonadotropic Hypogonadism

Klinefelter Syndrome	Klinefelter'S Syndrome
Xxy Syndrome	Xxy Trisomy
Hypogonadotropism	47, Xxy
Congenital Idiopathic Hypogonadotropic Hypogonadism	Isolated Congenital Gonadotropin Deficiency
47,Xxy Syndrome	47, Xxy Syndrome
Klinefelters Syndrome	Hypogonadism
Klinefelter Syndrome In Males	Klinefelter Syndrome, Unspecified
Klinefelter Syndrome Karyotype 47, Xxy

Persistent Mullerian Duct Syndrome

Persistent Müllerian Duct Syndrome	Pmds
Persistent Oviduct Syndrome	Persistent Muellerian Duct Syndrome
Female Genital Ducts In Otherwise Normal Male	Hernia Uteri Inguinale
Persistent Mullerian Duct Syndrome, Types 1 And 2	Persistent Mullerian Derivatives

Spermatocele

Disorder Of Sexual Development

Disorder Of Sex Development	Sex Development Disorder
Sex Differentiation Disease	Dsd
Disorders Of Sex Development	Sex Differentiation Disorders

Mullerian Duct Aplasia, Unilateral Renal Agenesis, And Cervicothoracic Somite Anomalies

Murcs Association	Mayer-Rokitansky-Kuster-Hauser Syndrome Type 2
Mrkh Syndrome Type 2	Mayer-Rokitansky-Küster-Hauser Syndrome Type 2
MURCS	Klippel-Feil Deformity, Conductive Deafness, And Absent Vagina
Atypical Mrkh Syndrome	Mullerian Duct Aplasia-Renal Dysplasia-Cervical Somite Anomalies Syndrome
Mayer-Rokitansky-Kuster-Hauser Syndrome, Type Ii	Mrkh, Type Ii
Mullerian Duct Aplasia, Unilateral Renal Aplasia, And Cervicothoracic Somite Dysplasia	Klippel-Feil Deformity - Conductive Deafness - Absent Vagina
Müllerian Aplasia - Renal Aplasia - Cervicothoracic Somite Dysplasia

Mixed Gonadal Dysgenesis

Gonadal Dysgenesis Mixed

Gonadal Dysgenesis, Mixed

Mayer-Rokitansky-Kuster-Hauser Syndrome

Mrkh Syndrome	Rokitansky Syndrome
Mullerian Aplasia	Mrkh Anomaly
Congenital Absence Of Uterus And Vagina	Congenital Absence Of The Uterus And Vagina
Genital Renal Ear Syndrome	Mayer-Rokitansky-Küster-Hauser Syndrome
Mullerian Dysgenesis	Müllerian Agenesis
Rokitansky Kuster Hauser Syndrome	MRKH
Mullerian Aplasia/Dysgenesis	Von Mayer-Rokitansky-Kuster Anomaly
Mrk Anomaly	Uterus Bipartitus Solidus Rudimentarius Cum Vagina Solida
Cauv	Mullerian Agenesis
Aplasia Of The Mullerian Ducts	Mullerian Duct Failure
Müllerian Aplasia	Rokitansky-Kuster-Hauser Syndrome
RKH SYNDROME

Gonadal Dysgenesis

Gonadal Dysgenesis Syndrome

Turner Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS00654	AMHR2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS00655	Amhr2 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS00656	Amhr2 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	AMHR2	VGNC	VGNC:67494
Mus musculus	AMHR2	MGD	MGI:105062
Macaca mulatta	AMHR2	VGNC	VGNC:69805
Bos taurus	AMHR2	VGNC	VGNC:54403
Canis familiaris	AMHR2	VGNC	VGNC:37830
Rattus norvegicus	AMHR2	RGD	RGD:70964
Macaca fascicularis	AMHR2	NCBI	NCBI:102117592
Others	AMHR2	NCBI

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