CD109 - CD109 molecule Gene

Also Known as p180; r150; CPAMD7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 135228

About CD109

Cytogenetic location: 6q13 Genomic coordinates (GRCh38): 6:73,679,192-73,828,313 (from NCBI)

This gene has 5 transcripts (splice variants), 227 orthologues, 8 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 9.8), endometrium (RPKM 7.6) and 21 other tissues.

Summary

This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

CD109 Products (3)

mRNA Protein Name
NM_001159587.3 NP_001153059.1 CD109 antigen isoform 2 preproprotein
NM_001159588.3 NP_001153060.1 CD109 antigen isoform 3 preproprotein
NM_133493.5 NP_598000.2 CD109 antigen isoform 1 preproprotein

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
16754747 GOA
involved in negative regulation of wound healing IDA
IDA: Inferred from direct assay
16754747 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD109 Protein Structure

A2M_N

A2M_N: MG2 domain (131 - 221)

A2M_N_2

A2M_N_2: Alpha-2-macroglobulin family N-terminal region (468 - 599)

A2M

A2M: Alpha-2-macroglobulin family (693 - 782)

Thiol-ester_cl

Thiol-ester_cl: Alpha-macro-globulin thiol-ester bond-forming region (910 - 940)

A2M_comp

A2M_comp: A-macroglobulin complement component (959 - 1195)

A2M_recep

A2M_recep: A-macroglobulin receptor (1311 - 1395)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1445 a.a.
Protein Preferred Names Protein Names

CD109 antigen

  • 150 kDa TGF-beta-1-binding protein

CD109 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84647 CD109 Antibody (YA4344) IHC-P, ICC/IF, FC, ELISA Human
HY-P84647A CD109 Antibody (YA4344)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Fetal And Neonatal Alloimmune Thrombocytopenia

  • Nait

  • Neonatal Alloimmune Thrombocytopenia

  • Fnait
Adenosquamous Gallbladder Carcinoma

  • Adenosquamous Carcinoma Of Gallbladder

  • Adenosquamous Carcinoma Of The Gallbladder

  • Gallbladder Adenosquamous Carcinoma
Gallbladder Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of The Gallbladder

  • Epidermoid Gallbladder Carcinoma
Immunodeficiency 15b

  • IMD15B

  • Immunodeficiency, Type 15b
Myxofibrosarcoma

  • Fibromyxosarcoma

  • Fibromyxoid Sarcoma

  • Myxoid Malignant Fibrous Histiocytoma

  • Dermatofibrosarcoma Protuberans, Myxoid
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02188 CD109 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19660 Cd109 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26153 Cd109 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CD109 VGNC VGNC:38929
Felis catus CD109 VGNC VGNC:60583
Bos taurus CD109 VGNC VGNC:27002
Mus musculus CD109 MGD MGI:2445221
Rattus norvegicus CD109 RGD RGD:1311287
Macaca mulatta CD109 VGNC VGNC:70834
Others CD109 NCBI