RNF187 - ring finger protein 187 Gene

Also Known as RACO1; RACO-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 149603

About RNF187

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:228,487,382-228,496,188 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele and 64 orthologues. Ubiquitous expression in thyroid (RPKM 54.8), brain (RPKM 49.5) and 25 other tissues.

Summary

Enables ubiquitin-protein transferase activity. Involved in positive regulation of transcription, DNA-templated; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RNF187 Products (1)

mRNA Protein Name
NM_001010858.3 NP_001010858.2 E3 ubiquitin-protein ligase RNF187

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20852630 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
20852630 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
20852630 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
20852630 GOA
involved in protein K48-linked ubiquitination IMP
IMP: Inferred from mutant phenotype
20852630 GOA
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
20852630 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20852630 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20852630 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF187

  • RING domain AP1 coactivator 1

RNF187 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RNF187 Q5TA31 ZNF835 Homo sapiens Q9Y2P0
Validated Y2H
32296183
Intra
RNF187 Q5TA31 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypermobility Of Coccyx

  • Coccygeal Hypermobility Syndrome

  • Hypermobility Of The Coccyx
Klippel-Feil Syndrome 3
Kummell'S Disease

  • Traumatic Spondylopathy

  • Kummell Disease

  • Kummell'S Spondylitis

  • Kümmelll-Verneuil Disease

  • Kümmell Spondylitis

  • Kümmell Disease

  • Traumatic Spondylosis
Brown-Sequard Syndrome

  • Brown-Squard Syndrome

  • Hemicord Syndrome

  • Hemiparaplegic Syndrome

  • Hemispinal Cord Syndrome

  • Brown-Séquard Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12071 RNF187 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RNF187 RGD RGD:1308636
Bos taurus RNF187 VGNC VGNC:50124
Macaca mulatta RNF187 VGNC VGNC:100059
Mus musculus RNF187 MGD MGI:1914224
Others RNF187 NCBI