CFAP45 - cilia and flagella associated protein 45 Gene

Also Known as HTX11; NESG1; CCDC19

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25790

About CFAP45

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:159,872,364-159,900,165 (from NCBI)

This gene has 6 transcripts (splice variants), 207 orthologues and is associated with 1 phenotype. Biased expression in testis (RPKM 17.3), lung (RPKM 4.0) and 1 other tissue.

Summary

Enables AMP binding activity. Involved in establishment of left/right asymmetry and flagellated sperm motility. Located in 9+2 motile cilium; axoneme; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CFAP45 Products (1)

mRNA	Protein	Name
NM_012337.3	NP_036469.2	cilia- and flagella-associated protein 45

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables AMP binding	IDA IDA: Inferred from direct assay	33139725	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in establishment of left/right asymmetry	IMP IMP: Inferred from mutant phenotype	33139725	GOA
involved in flagellated sperm motility	IMP IMP: Inferred from mutant phenotype	33139725	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in 9+2 motile cilium	IDA IDA: Inferred from direct assay	33139725	GOA
located in axonemal microtubule	IDA IDA: Inferred from direct assay	36191189	GOA
located in axoneme	IDA IDA: Inferred from direct assay	33139725	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CFAP45 Protein Structure

TPH

0
100
200
300
400
500
551 a.a.

Protein Preferred Names	Protein Names
cilia- and flagella-associated protein 45	coiled-coil domain containing 19

CFAP45 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CFAP45	Q9UL16	ENKUR	Homo sapiens	Q8TC29	Y2H Array	32296183
Intra	CFAP45	Q9UL16	ENKUR	Homo sapiens	Q8TC29	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Heterotaxy, Visceral, 11, Autosomal, With Male Infertility	HTX11
Visceral Heterotaxy	Situs Ambiguus Heterotaxia Heterotaxy Syndrome Heterotaxy Lateralization Defect Situs Ambiguous Left Isomerism Htx Ivemark Syndrome Right Isomerism Situs Ambiguus Viscerum Incomplete Situs Inversus Partial Situs Inversus Heterotaxy, Visceral Asplenia Syndrome Bilateral Left-Sidedness Polysplenia Syndrome Moller Syndrome
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02553	CFAP45 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CFAP45	VGNC	VGNC:39163
Felis catus	CFAP45	VGNC	VGNC:60814
Mus musculus	CFAP45	MGD	MGI:1919120
Rattus norvegicus	CFAP45	RGD	RGD:1561559
Bos taurus	CFAP45	VGNC	VGNC:27244
Macaca mulatta	CFAP45	VGNC	VGNC:70963
Others	CFAP45	NCBI