CFAP45 - cilia and flagella associated protein 45 Gene

Homo sapiens

Also known as HTX11; NESG1; CCDC19

Gene ID: 25790 | Gene type: protein coding

About CFAP45

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:159,872,364-159,900,165 (from NCBI)

This gene has 6 transcripts (splice variants), 207 orthologues and is associated with 1 phenotype. Biased expression in testis (RPKM 17.3), lung (RPKM 4.0) and 1 other tissue.

Summary

Enables AMP binding activity. Involved in establishment of left/right asymmetry and flagellated sperm motility. Located in 9+2 motile cilium; axoneme; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CFAP45 Products(1)

mRNA	Protein	Name
NM_012337.3	NP_036469.2	cilia- and flagella-associated protein 45

CFAP45 Protein Structure

TPH

0
100
200
300
400
500
551 a.a.

Protein Preferred Names

Protein Names

cilia- and flagella-associated protein 45

coiled-coil domain containing 19

Related Diseases

Diseases

Alias

Heterotaxy, Visceral, 11, Autosomal, With Male Infertility

HTX11

Visceral Heterotaxy

Situs Ambiguus	Heterotaxia
Heterotaxy Syndrome	Heterotaxy
Lateralization Defect	Situs Ambiguous
Left Isomerism	Htx
Ivemark Syndrome	Right Isomerism
Situs Ambiguus Viscerum	Incomplete Situs Inversus
Partial Situs Inversus	Heterotaxy, Visceral
Asplenia Syndrome	Bilateral Left-Sidedness
Polysplenia Syndrome	Moller Syndrome

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02553	CFAP45 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CFAP45	VGNC	VGNC:39163
Felis catus	CFAP45	VGNC	VGNC:60814
Mus musculus	CFAP45	MGD	MGI:1919120
Rattus norvegicus	CFAP45	RGD	RGD:1561559
Bos taurus	CFAP45	VGNC	VGNC:27244
Macaca mulatta	CFAP45	VGNC	VGNC:70963

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