Nrip1 - nuclear receptor interacting protein 1 Gene

Also Known as RIP140; 9630050P12; 6030458L20Rik; 8430438I05Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 268903

Summary

Enables several functions, including histone deacetylase binding activity; retinoid X receptor binding activity; and transcription coactivator activity. Involved in circadian regulation of gene expression; lipid storage; and ovarian follicle rupture. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nuclear speck. Part of histone deacetylase complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in CAKUT and osteoporosis. Orthologous to human NRIP1 (nuclear receptor interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Nrip1 Products (2)

mRNA	Protein	Name
NM_001358238.1	NP_001345167.1	nuclear receptor-interacting protein 1
NM_173440.3	NP_775616.1	nuclear receptor-interacting protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	11006275	MGI
enables nuclear retinoic acid receptor binding	IPI IPI: Inferred from physical interaction	10531331	MGI
enables nuclear retinoid X receptor binding	IPI IPI: Inferred from physical interaction	10531331	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9774688	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	9774688	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	21628546	MGI
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	9774688	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21628546	MGI
involved in lipid storage	IMP IMP: Inferred from mutant phenotype	15155905	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9774688	MGI
involved in ovarian follicle rupture	IMP IMP: Inferred from mutant phenotype	15919748	MGI
involved in ovulation	IMP IMP: Inferred from mutant phenotype	11100122	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19796622	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of histone deacetylase complex	IPI IPI: Inferred from physical interaction	11278635	MGI
located in nuclear speck	IDA IDA: Inferred from direct assay	23071095	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15879431	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
nuclear receptor-interacting protein 1	nuclear factor RIP140 receptor-interacting protein 140

Nrip1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Nrip1	Q8CBD1	HDAC3	Homo sapiens	O15379	Anti Tag CoIP	11006275

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09571	NRIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22690	Nrip1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29204	Nrip1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nrip1	NCBI	NCBI:8204