Lgi1 - leucine-rich repeat LGI family, member 1 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56839

Summary

Involved in neurotransmitter receptor localization to postsynaptic specialization membrane. Located in extracellular space and glutamatergic synapse. Is active in synaptic cleft. Is expressed in several structures, including central nervous system; diaphragm; sensory organ; and skeletal musculature. Used to study familial temporal lobe epilepsy 1. Human ortholog(s) of this gene implicated in familial temporal lobe epilepsy 1. Orthologous to human LGI1 (leucine rich glioma inactivated 1). [provided by Alliance of Genome Resources, Apr 2022]

Lgi1 Products (1)

mRNA Protein Name
NM_020278.3 NP_064674.1 leucine-rich glioma-inactivated protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18974846 MGI
Biological Process GO Annotation Evidence References Source
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
20133599 MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
20133599 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
26269648 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
15857855 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20133599 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
20133599 MGI
is active in synaptic cleft IDA
IDA: Inferred from direct assay
20133599 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leucine-rich glioma-inactivated protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07613 LGI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22218 Lgi1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28740 Lgi1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lgi1 NCBI NCBI:9211