CHPT1 - choline phosphotransferase 1 Gene

Also Known as CPT; CPT1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56994

About CHPT1

Cytogenetic location: 12q23.2 Genomic coordinates (GRCh38): 12:101,697,640-101,729,074 (from NCBI)

This gene has 10 transcripts (splice variants), 213 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 11.8), duodenum (RPKM 11.3) and 25 other tissues.

Summary

Enables diacylglycerol cholinephosphotransferase activity. Involved in phosphatidylcholine biosynthetic process and platelet activating factor biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

CHPT1 Products (1)

mRNA Protein Name
NM_020244.3 NP_064629.2 cholinephosphotransferase 1

CHPT1 Protein Structure

CDP-OH_P_transf

CDP-OH_P_transf: CDP-alcohol phosphatidyltransferase (60 - 165)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
Protein Preferred Names Protein Names

cholinephosphotransferase 1

  • AAPT1-like protein

CHPT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CHPT1 Q8WUD6 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra
CHPT1 Q8WUD6 TLCD4 Homo sapiens Q96MV1
Validated Y2H
32296183
Intra
CHPT1 Q8WUD6 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neuronopathy, Distal Hereditary Motor, Type Viia

  • HMN7A

  • Hmn Viia

  • Dhmn7a

  • Neuropathy, Distal Hereditary Motor, Type Viia

  • Dhmnvp

  • Harper-Young Myopathy

  • Distal Hereditary Motor Neuronopathy Type 7a

  • Distal Hereditary Motor Neuropathy Type Viia

  • Neuronopathy, Distal Hereditary Motor, Type 7a

  • Spinal Muscular Atrophy, Distal, With Vocal Cord Paralysis

  • Distal Spinal Muscular Atrophy With Vocal Cord Paralysis Type 7a

  • Harper-Young Myopath

  • Neuronopathy, Distal Hereditary Motor, 7a

  • Distal Hereditary Motor Neuronopathy Type Viia

  • Distal Hereditary Motor Neuropathy With Vocal Cord Paralysis

  • Distal Spinal Muscular Atrophy With Vocal Cord Paralysis

  • Neuropathy, Motor, Distal, Hereditary, Type Viia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02655 CHPT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20377 Chpt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26887 Chpt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CHPT1 VGNC VGNC:54196
Bos taurus CHPT1 VGNC VGNC:27314
Macaca mulatta CHPT1 VGNC VGNC:70989
Felis catus CHPT1 VGNC VGNC:60869
Mus musculus CHPT1 MGD MGI:2384841
Rattus norvegicus CHPT1 RGD RGD:1359283
Others CHPT1 NCBI