HTRA3 - HtrA serine peptidase 3 Gene

Also Known as Prsp; Tasp

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 94031

About HTRA3

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:8,269,754-8,307,098 (from NCBI)

This gene has 2 transcripts (splice variants), 192 orthologues and 3 paralogues. Broad expression in ovary (RPKM 19.8), gall bladder (RPKM 16.9) and 19 other tissues.

Summary

Enables endopeptidase activity; identical protein binding activity; and serine-type peptidase activity. Involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

HTRA3 Products (2)

mRNA Protein Name
NM_001297559.3 NP_001284488.1 serine protease HTRA3 isoform 2 precursor
NM_053044.5 NP_444272.1 serine protease HTRA3 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables endopeptidase activity IDA
IDA: Inferred from direct assay
18387192 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
26110759 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22229724 GOA
enables serine-type peptidase activity IDA
IDA: Inferred from direct assay
22229724 GOA
Biological Process GO Annotation Evidence References Source
involved in proteolysis IDA
IDA: Inferred from direct assay
18387192 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTRA3 Protein Structure

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (81 - 126)

Trypsin_2

Trypsin_2: Trypsin-like peptidase domain (175 - 319)

PDZ_2

PDZ_2: PDZ domain (356 - 431)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 453 a.a.
Protein Preferred Names Protein Names

serine protease HTRA3

  • high-temperature requirement factor A3

HTRA3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HTRA3 P83110 HTRA4 Homo sapiens P83105
Anti Tag CoIP
25002585
Intra
HTRA3 P83110 HTRA3 Homo sapiens P83110
GMS
26110759
Intra
HTRA3 P83110 XIAP Homo sapiens P98170
Anti Bait CoIP
31260151
Intra
HTRA3 P83110 ACTB Homo sapiens P60709
Anti Bait CoIP
29477555
Intra
HTRA3 P83110 XIAP Homo sapiens P98170
PLA
31260151
Intra
HTRA3 P83110 XIAP Homo sapiens P98170
Pull Down
31260151
Intra
HTRA3 P83110 XIAP Homo sapiens P98170
Confocal
31260151
Intra
HTRA3 P83110 HTRA3 Homo sapiens P83110
GMS
31899476
Intra
HTRA3 P83110 HTRA3 Homo sapiens P83110
X-Ray Diffraction
26110759
Intra
HTRA3 P83110 TCP1 Homo sapiens P17987
Anti Bait CoIP
29477555
Cross
HTRA3 P83110 CSN2 Bos taurus P02666
GMS
26110759
Cross
HTRA3 P83110 CSN2 Bos taurus P02666
Protease Assay
26110759
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Endometrial Cancer

  • Endometrial Carcinoma

  • Endometrial Neoplasm

  • Malignant Neoplasm Of Endometrium

  • Endometrioid Carcinoma

  • Endometrial Neoplasms

  • Carcinoma, Endometrioid

  • Endometrial Cancer, Familial

  • Endometrial Carcinoma, Somatic

  • Endometrial Cancer, Susceptibility To

  • Endometrial Ca

  • Malignant Endometrial Neoplasm

  • Neoplasm Of Endometrium

  • Primary Malignant Neoplasm Of Endometrium

  • Tumor Of Endometrium

  • Carcinoma Of The Endometrium

  • Endometrioid Carcinoma Of Female Reproductive System

  • ENDMC

  • Carcinoma Endometrioid

  • Endometrial Cancers

  • Cancer, Endometrial

  • Uterine Corpus Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01891 CAPN5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06488 HTRA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27386 Capn5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HTRA3 MGD MGI:1925808
Felis catus HTRA3 VGNC VGNC:62856
Bos taurus HTRA3 VGNC VGNC:59337
Canis familiaris HTRA3 VGNC VGNC:41837
Rattus norvegicus HTRA3 RGD RGD:1308120
Macaca mulatta HTRA3 VGNC VGNC:82160
Others HTRA3 NCBI