TCP1 - t-complex 1 Gene
Also Known as CCT1; CCTa; D6S230E; CCT-alpha; TCP-1-alpha
Species: Homo sapiens
About TCP1
This gene has 18 transcripts (splice variants), 228 orthologues and 13 paralogues. Ubiquitous expression in testis (RPKM 91.3), brain (RPKM 50.5) and 25 other tissues.
Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]
TCP1 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001008897.2 | NP_001008897.1 | T-complex protein 1 subunit alpha isoform b |
| NM_030752.3 | NP_110379.2 | T-complex protein 1 subunit alpha isoform a |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
14532270 | GOA |
| enables protein folding chaperone |
IDA
IDA: Inferred from direct assay
|
25467444 | GOA |
| enables ubiquitin protein ligase binding |
IPI
IPI: Inferred from physical interaction
|
21753002 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in chaperone mediated protein folding independent of cofactor |
IMP
IMP: Inferred from mutant phenotype
|
25467444 | GOA |
| involved in chaperone-mediated protein folding |
IDA
IDA: Inferred from direct assay
|
22133715 | GOA |
| acts upstream of positive regulation of establishment of protein localization to telomere |
IMP
IMP: Inferred from mutant phenotype
|
25467444 | GOA |
| involved in positive regulation of telomerase RNA localization to Cajal body |
IMP
IMP: Inferred from mutant phenotype
|
25467444 | GOA |
| acts upstream of positive regulation of telomere maintenance via telomerase |
IMP
IMP: Inferred from mutant phenotype
|
25467444 | GOA |
| involved in protein folding |
IDA
IDA: Inferred from direct assay
|
30955883 | GOA |
| involved in protein stabilization |
IMP
IMP: Inferred from mutant phenotype
|
25467444 | GOA |
| acts upstream of positive effect scaRNA localization to Cajal body |
IMP
IMP: Inferred from mutant phenotype
|
25467444 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in centrosome |
IDA
IDA: Inferred from direct assay
|
20080638 | GOA |
| part of chaperonin-containing T-complex |
IDA
IDA: Inferred from direct assay
|
23011926 | GOA |
| part of chaperonin-containing T-complex |
IPI
IPI: Inferred from physical interaction
|
22133715 | GOA |
| located in microtubule |
IDA
IDA: Inferred from direct assay
|
21525035 | GOA |
TCP1 Protein Structure
Cpn60_TCP1: TCP-1/cpn60 chaperonin family (28 - 532)
- 0
- 100
- 200
- 300
- 400
- 500
- 556 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
T-complex protein 1 subunit alpha |
|
TCP1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
TCP1 | P17987 | HTRA3 | Homo sapiens | P83110-2 | 29477555 | |
|
Intra
|
TCP1 | P17987 | HTRA3 | Homo sapiens | P83110-2 | 29477555 | |
|
Intra
|
TCP1 | P17987 | HTRA3 | Homo sapiens | P83110-2 | 29477555 | |
|
Intra
|
TCP1 | P17987 | BRPF3 | Homo sapiens | Q9ULD4-2 | 32814053 | |
|
Intra
|
TCP1 | P17987 | BRPF3 | Homo sapiens | Q9ULD4-2 | 32814053 | |
|
Intra
|
TCP1 | P17987 | BRPF3 | Homo sapiens | Q9ULD4-2 | 32814053 | |
|
Intra
|
TCP1 | P17987 | HTRA3 | Homo sapiens | P83110-1 | 29477555 | |
|
Intra
|
TCP1 | P17987 | HTRA3 | Homo sapiens | P83110-1 | 29477555 | |
|
Intra
|
TCP1 | P17987 | HTRA3 | Homo sapiens | P83110 | 29477555 | |
|
Intra
|
TCP1 | P17987 | HTRA3 | Homo sapiens | P83110 | 29477555 | |
|
Intra
|
TCP1 | P17987 | ARL2BP | Homo sapiens | Q9Y2Y0 | 32814053 | |
|
Intra
|
TCP1 | P17987 | ARL2BP | Homo sapiens | Q9Y2Y0 | 32814053 | |
|
Intra
|
TCP1 | P17987 | ARL2BP | Homo sapiens | Q9Y2Y0 | 32814053 | |
|
Intra
|
TCP1 | P17987 | CCT8 | Homo sapiens | P50990 | 16085932 | |
|
Intra
|
TCP1 | P17987 | CCT8 | Homo sapiens | P50990 | 30021884 | |
|
Intra
|
TCP1 | P17987 | CCT4 | Homo sapiens | P50991 | 30021884 | |
|
Intra
|
TCP1 | P17987 | CCT4 | Homo sapiens | P50991 | 16085932 | |
|
Intra
|
TCP1 | P17987 | CCT2 | Homo sapiens | P78371 | 16097032 | |
|
Intra
|
TCP1 | P17987 | CCT2 | Homo sapiens | P78371 | 16085932 | |
|
Intra
|
TCP1 | P17987 | CCT2 | Homo sapiens | P78371 | 30021884 | |
|
Intra
|
TCP1 | P17987 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
TCP1 | P17987 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
TCP1 | P17987 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
TCP1 | P17987 | OLR1 | Homo sapiens | P78380 | 24846140 | |
|
Intra
|
TCP1 | P17987 | OLR1 | Homo sapiens | P78380 | 24846140 | |
|
Intra
|
TCP1 | P17987 | CBFA2T2 | Homo sapiens | O43439 | 25416956 |
TCP1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82493 | TCP 1 alpha Antibody (YA2238) | WB, IHC-P, ICC/IF, IP | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Intellectual Developmental Disorder, Autosomal Dominant 48 |
|
|
| Down Syndrome |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | TCP1 | VGNC | VGNC:66034 |
| Macaca mulatta | TCP1 | VGNC | VGNC:83494 |
| Rattus norvegicus | TCP1 | RGD | RGD:3832 |
| Mus musculus | TCP1 | MGD | MGI:98535 |
| Bos taurus | TCP1 | VGNC | VGNC:35701 |
| Canis familiaris | TCP1 | VGNC | VGNC:47207 |
| Others | TCP1 | NCBI |