TCP1 - t-complex 1 Gene

Also Known as CCT1; CCTa; D6S230E; CCT-alpha; TCP-1-alpha

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6950

About TCP1

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:159,778,498-159,789,602 (from NCBI)

This gene has 18 transcripts (splice variants), 228 orthologues and 13 paralogues. Ubiquitous expression in testis (RPKM 91.3), brain (RPKM 50.5) and 25 other tissues.

Summary

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]

TCP1 Products (2)

mRNA Protein Name
NM_001008897.2 NP_001008897.1 T-complex protein 1 subunit alpha isoform b
NM_030752.3 NP_110379.2 T-complex protein 1 subunit alpha isoform a
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14532270 GOA
enables protein folding chaperone IDA
IDA: Inferred from direct assay
25467444 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
21753002 GOA
Biological Process GO Annotation Evidence References Source
involved in chaperone mediated protein folding independent of cofactor IMP
IMP: Inferred from mutant phenotype
25467444 GOA
involved in chaperone-mediated protein folding IDA
IDA: Inferred from direct assay
22133715 GOA
acts upstream of positive regulation of establishment of protein localization to telomere IMP
IMP: Inferred from mutant phenotype
25467444 GOA
involved in positive regulation of telomerase RNA localization to Cajal body IMP
IMP: Inferred from mutant phenotype
25467444 GOA
acts upstream of positive regulation of telomere maintenance via telomerase IMP
IMP: Inferred from mutant phenotype
25467444 GOA
involved in protein folding IDA
IDA: Inferred from direct assay
30955883 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
25467444 GOA
acts upstream of positive effect scaRNA localization to Cajal body IMP
IMP: Inferred from mutant phenotype
25467444 GOA
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
20080638 GOA
part of chaperonin-containing T-complex IDA
IDA: Inferred from direct assay
23011926 GOA
part of chaperonin-containing T-complex IPI
IPI: Inferred from physical interaction
22133715 GOA
located in microtubule IDA
IDA: Inferred from direct assay
21525035 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCP1 Protein Structure

Cpn60_TCP1

Cpn60_TCP1: TCP-1/cpn60 chaperonin family (28 - 532)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 556 a.a.
Protein Preferred Names Protein Names

T-complex protein 1 subunit alpha

  • T-complex protein 1, alpha subunit

TCP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TCP1 P17987 HTRA3 Homo sapiens P83110-2 29477555
Intra
TCP1 P17987 HTRA3 Homo sapiens P83110-2 29477555
Intra
TCP1 P17987 HTRA3 Homo sapiens P83110-2
MST
29477555
Intra
TCP1 P17987 BRPF3 Homo sapiens Q9ULD4-2 32814053
Intra
TCP1 P17987 BRPF3 Homo sapiens Q9ULD4-2 32814053
Intra
TCP1 P17987 BRPF3 Homo sapiens Q9ULD4-2 32814053
Intra
TCP1 P17987 HTRA3 Homo sapiens P83110-1
MST
29477555
Intra
TCP1 P17987 HTRA3 Homo sapiens P83110-1 29477555
Intra
TCP1 P17987 HTRA3 Homo sapiens P83110 29477555
Intra
TCP1 P17987 HTRA3 Homo sapiens P83110 29477555
Intra
TCP1 P17987 ARL2BP Homo sapiens Q9Y2Y0 32814053
Intra
TCP1 P17987 ARL2BP Homo sapiens Q9Y2Y0 32814053
Intra
TCP1 P17987 ARL2BP Homo sapiens Q9Y2Y0 32814053
Intra
TCP1 P17987 CCT8 Homo sapiens P50990
TAP
16085932
Intra
TCP1 P17987 CCT8 Homo sapiens P50990 30021884
Intra
TCP1 P17987 CCT4 Homo sapiens P50991 30021884
Intra
TCP1 P17987 CCT4 Homo sapiens P50991
TAP
16085932
Intra
TCP1 P17987 CCT2 Homo sapiens P78371 16097032
Intra
TCP1 P17987 CCT2 Homo sapiens P78371
TAP
16085932
Intra
TCP1 P17987 CCT2 Homo sapiens P78371 30021884
Intra
TCP1 P17987 HTT Homo sapiens P42858 32814053
Intra
TCP1 P17987 HTT Homo sapiens P42858 32814053
Intra
TCP1 P17987 HTT Homo sapiens P42858 32814053
Intra
TCP1 P17987 OLR1 Homo sapiens P78380
IF
24846140
Intra
TCP1 P17987 OLR1 Homo sapiens P78380 24846140
Intra
TCP1 P17987 CBFA2T2 Homo sapiens O43439 25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

TCP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82493 TCP 1 alpha Antibody (YA2238) WB, IHC-P, ICC/IF, IP Human

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, Autosomal Dominant 48
  • Mental Retardation, Autosomal Dominant 48

  • MRD48

  • Autosomal Dominant Mental Retardation 48

  • Autosomal Dominant Intellectual Developmental Disorder 48

Down Syndrome
  • Trisomy 21

  • Complete Trisomy 21 Syndrome

  • Down'S Syndrome

  • Trisomy 21 Syndrome

  • Down'S Syndrome - Trisomy 21

  • Downs Syndrome

  • G Trisomy

  • 47,Xx,+21

  • 47,Xy,+21

  • Trisomy G

  • Down Syndrome, Susceptibility To

  • Chromosome 21 Trisomy

  • Trisomy 21 Nos

  • Abnormal Autosomes 21

Alzheimer Disease, Familial, 1
  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus TCP1 VGNC VGNC:66034
Macaca mulatta TCP1 VGNC VGNC:83494
Rattus norvegicus TCP1 RGD RGD:3832
Mus musculus TCP1 MGD MGI:98535
Bos taurus TCP1 VGNC VGNC:35701
Canis familiaris TCP1 VGNC VGNC:47207
Others TCP1 NCBI