CCT4 - chaperonin containing TCP1 subunit 4 Gene

Also Known as SRB; Cctd; CCT-DELTA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10575

About CCT4

Cytogenetic location: 2p15 Genomic coordinates (GRCh38): 2:61,868,085-61,888,671 (from NCBI)

This gene has 4 transcripts (splice variants), 227 orthologues and 13 paralogues. Ubiquitous expression in ovary (RPKM 58.5), testis (RPKM 51.7) and 25 other tissues.

Summary

The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]

CCT4 Products (2)

mRNA Protein Name
NM_001256721.1 NP_001243650.1 T-complex protein 1 subunit delta isoform b
NM_006430.4 NP_006421.2 T-complex protein 1 subunit delta isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16085932 GOA
enables protein folding chaperone IDA
IDA: Inferred from direct assay
25467444 GOA
Biological Process GO Annotation Evidence References Source
involved in chaperone mediated protein folding independent of cofactor IMP
IMP: Inferred from mutant phenotype
25467444 GOA
involved in chaperone-mediated protein folding IDA
IDA: Inferred from direct assay
22133715 GOA
involved in positive regulation of telomerase RNA localization to Cajal body IMP
IMP: Inferred from mutant phenotype
25467444 GOA
acts upstream of positive regulation of telomere maintenance via telomerase IMP
IMP: Inferred from mutant phenotype
25467444 GOA
involved in protein folding IDA
IDA: Inferred from direct assay
30955883 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
25467444 GOA
acts upstream of positive effect scaRNA localization to Cajal body IMP
IMP: Inferred from mutant phenotype
25467444 GOA
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
20080638 GOA
part of chaperonin-containing T-complex IDA
IDA: Inferred from direct assay
23011926 GOA
part of chaperonin-containing T-complex IPI
IPI: Inferred from physical interaction
22133715 GOA
located in microtubule IDA
IDA: Inferred from direct assay
21525035 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCT4 Protein Structure

Cpn60_TCP1

Cpn60_TCP1: TCP-1/cpn60 chaperonin family (44 - 538)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 539 a.a.
Protein Preferred Names Protein Names

T-complex protein 1 subunit delta

  • TCP-1-delta

CCT4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CCT4 P50991 TCP1 Homo sapiens P17987
Anti Tag CoIP
35271311
Intra
CCT4 P50991 CCT2 Homo sapiens P78371
Anti Tag CoIP
35271311
Intra
CCT4 P50991 CCT2 Homo sapiens P78371
Validated Y2H
32296183
Intra
CCT4 P50991 OLR1 Homo sapiens P78380
Pull Down
24846140
Intra
CCT4 P50991 CCNH Homo sapiens P51946
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Sensory Peripheral Neuropathy

  • Sensory Neuropathy

  • Peripheral Sensory Neuropathy

  • Hereditary Sensory And Autonomic Neuropathies
Posterior Cerebral Artery Infarction

  • Infarction, Posterior Cerebral Artery
Peroxisome Biogenesis Disorder 11a

  • PBD11A

  • Peroxisome Biogenesis Disorder Complementation Group 13

  • PBD-CG13

  • Cg13

  • Pbd-Cgh

  • Peroxisome Biogenesis Disorder Complementation Group H

  • Peroxisome Biogenesis Disorder, Type 11a

  • Peroxisome Biogenesis Disorder, Complementation Group 13
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02181 CCT4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22113 Cct4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28635 Cct4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CCT4 VGNC VGNC:26997
Felis catus CCT4 VGNC VGNC:60578
Canis familiaris CCT4 VGNC VGNC:38924
Mus musculus CCT4 MGD MGI:104689
Macaca mulatta CCT4 VGNC VGNC:70747
Rattus norvegicus CCT4 RGD RGD:727937
Others CCT4 NCBI