CCT8 - chaperonin containing TCP1 subunit 8 Gene

Also Known as Cctq; PRED71; D21S246; C21orf112

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10694

About CCT8

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:29,056,326-29,073,648 (from NCBI)

This gene has 12 transcripts (splice variants), 212 orthologues and 13 paralogues. Ubiquitous expression in adrenal (RPKM 57.9), lymph node (RPKM 57.3) and 25 other tissues.

Summary

This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]

CCT8 Products (4)

mRNA Protein Name
NM_001282907.2 NP_001269836.1 T-complex protein 1 subunit theta isoform 2
NM_001282908.2 NP_001269837.1 T-complex protein 1 subunit theta isoform 3
NM_001282909.2 NP_001269838.1 T-complex protein 1 subunit theta isoform 4
NM_006585.4 NP_006576.2 T-complex protein 1 subunit theta isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14532270 GOA
enables protein folding chaperone IDA
IDA: Inferred from direct assay
25467444 GOA
Biological Process GO Annotation Evidence References Source
involved in chaperone mediated protein folding independent of cofactor IMP
IMP: Inferred from mutant phenotype
25467444 GOA
involved in chaperone-mediated protein folding IDA
IDA: Inferred from direct assay
22133715 GOA
acts upstream of positive regulation of telomere maintenance via telomerase IMP
IMP: Inferred from mutant phenotype
25467444 GOA
involved in protein folding IDA
IDA: Inferred from direct assay
30955883 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
25467444 GOA
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
20080638 GOA
part of chaperonin-containing T-complex IDA
IDA: Inferred from direct assay
23011926 GOA
part of chaperonin-containing T-complex IPI
IPI: Inferred from physical interaction
22133715 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
25468996 GOA
located in microtubule IDA
IDA: Inferred from direct assay
21525035 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCT8 Protein Structure

Cpn60_TCP1

Cpn60_TCP1: TCP-1/cpn60 chaperonin family (39 - 529)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 548 a.a.
Protein Preferred Names Protein Names

T-complex protein 1 subunit theta

  • CCT-theta

CCT8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CCT8 P50990 BAG6 Homo sapiens P46379-2
Y2H Pooling
32814053
Intra
CCT8 P50990 BAG6 Homo sapiens P46379-2
Validated Y2H
32814053
Intra
CCT8 P50990 BAG6 Homo sapiens P46379-2
Y2H Array
32814053
Intra
CCT8 P50990 CDHR3 Homo sapiens Q6ZTQ4
Y2H Array
32814053
Intra
CCT8 P50990 CDHR3 Homo sapiens Q6ZTQ4
Validated Y2H
32814053
Intra
CCT8 P50990 CDHR3 Homo sapiens Q6ZTQ4
Y2H Pooling
32814053
Intra
CCT8 P50990 SNX12 Homo sapiens Q9UMY4
Validated Y2H
32814053
Intra
CCT8 P50990 SNX12 Homo sapiens Q9UMY4
Y2H Array
32814053
Intra
CCT8 P50990 SNX12 Homo sapiens Q9UMY4
Y2H Pooling
32814053
Intra
CCT8 P50990 TUBA1B Homo sapiens P68363-2
Validated Y2H
32814053
Intra
CCT8 P50990 TUBA1B Homo sapiens P68363-2
Y2H Array
32814053
Intra
CCT8 P50990 TUBA1B Homo sapiens P68363-2
Y2H Pooling
32814053
Intra
CCT8 P50990 TCP1 Homo sapiens P17987
Anti Tag CoIP
35271311
Intra
CCT8 P50990 CCT6A Homo sapiens P40227
Anti Tag CoIP
35271311
Intra
CCT8 P50990 CCT6A Homo sapiens P40227
Y2H Array
32814053
Intra
CCT8 P50990 CCT6A Homo sapiens P40227
Validated Y2H
32814053
Intra
CCT8 P50990 CCT6A Homo sapiens P40227
Y2H Pooling
32814053
Intra
CCT8 P50990 BRME1 Homo sapiens Q0VDD7
Validated Y2H
32814053
Intra
CCT8 P50990 BRME1 Homo sapiens Q0VDD7
Y2H Array
32814053
Intra
CCT8 P50990 BRME1 Homo sapiens Q0VDD7
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Otomycosis

  • Singapore Ear
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02185 CCT8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21307 Cct8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27826 Cct8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CCT8 VGNC VGNC:70749
Felis catus CCT8 VGNC VGNC:60582
Mus musculus CCT8 MGD MGI:107183
Canis familiaris CCT8 VGNC VGNC:38927
Rattus norvegicus CCT8 RGD RGD:1305452
Others CCT8 NCBI