CDHR3 - cadherin related family member 3 Gene

Also Known as CDH28

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 222256

About CDHR3

Cytogenetic location: 7q22.3 Genomic coordinates (GRCh38): 7:105,963,264-106,036,432 (from NCBI)

This gene has 14 transcripts (splice variants), 115 orthologues and 33 paralogues. Biased expression in lung (RPKM 2.7), stomach (RPKM 0.9) and 10 other tissues.

Summary

Predicted to enable Cadherin binding activity and calcium ion binding activity. Predicted to be involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell morphogenesis; and cell-cell junction organization. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

CDHR3 Products (2)

mRNA Protein Name
NM_001301161.2 NP_001288090.1 cadherin-related family member 3 isoform 2
NM_152750.5 NP_689963.2 cadherin-related family member 3 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
24241537 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDHR3 Protein Structure

Cadherin

Cadherin: Cadherin domain (146 - 226)

Cadherin

Cadherin: Cadherin domain (244 - 335)

Cadherin

Cadherin: Cadherin domain (466 - 557)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 885 a.a.
Protein Preferred Names Protein Names

cadherin-related family member 3

  • cadherin-like protein 28

CDHR3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CDHR3 Q6ZTQ4 NEIL2 Homo sapiens Q969S2
Validated Y2H
32296183
Intra
CDHR3 Q6ZTQ4 CXorf38 Homo sapiens Q8TB03
Validated Y2H
32296183
Intra
CDHR3 Q6ZTQ4 CLN3 Homo sapiens Q13286
Y2H Pooling
32814053
Intra
CDHR3 Q6ZTQ4 CLN3 Homo sapiens Q13286
Validated Y2H
32814053
Intra
CDHR3 Q6ZTQ4 CLN3 Homo sapiens Q13286
Y2H Array
32814053
Intra
CDHR3 Q6ZTQ4 SRP9 Homo sapiens P49458
Y2H Pooling
32814053
Intra
CDHR3 Q6ZTQ4 SRP9 Homo sapiens P49458
Validated Y2H
32814053
Intra
CDHR3 Q6ZTQ4 SRP9 Homo sapiens P49458
Y2H Array
32814053
Intra
CDHR3 Q6ZTQ4 PARVG Homo sapiens Q9HBI0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Acute Asthma
Childhood-Onset Asthma

  • Childhood Asthma

  • Asthma Childhood
Otitis Media

  • Opsoclonus-Myoclonus Syndrome

  • OMS

  • Otitis Media, Susceptibility To

  • Kinsbourne Syndrome

  • Otitis Media, Chronic/Recurrent

  • Come/Rom

  • Ataxo-Opso-Myoclonus Syndrome

  • Dancing Eye Syndrome

  • Dancing Eye-Dancing Feet Syndrome

  • Oma Syndrome

  • Opsoclonus Myoclonus Syndrome

  • Opsoclonus-Myoclonus-Ataxia Syndrome

  • Poma Syndrome

  • Paraneoplastic Opsoclonus-Myoclonus

  • Paraneoplastic Opsoclonus-Myoclonus-Ataxia Syndrome

  • Opsoclonus Myoclonus

  • OM

  • {Otitis Media, Susceptibility To}

  • Infectious Otitis Media
T2-High Asthma

  • Type 2 High Endotype
Chronic Asthma
Common Cold

  • Acute Coryza

  • Acute Nasopharyngitis

  • Acute Rhinitis

  • Acute Viral Rhinopharyngitis

  • Nasopharyngitis - Acute

  • Nasopharyngitis, Acute

  • Rhino-Sinusitis

  • Rhinosinusitis

  • Common Colds

  • Acute Infective Rhinitis

  • Cold

  • Coryza

  • Head Cold

  • Infective Nasopharyngitis

  • Rhinopharyngitis

  • Acute Nasal Catarrh

  • Infective Rhinitis

  • Acute Nasopharyngeal Catarrh

  • Infective Nasopharyngitis Nos

  • Nasopharyngitis Nos

  • Epipharyngitis

  • Mucositis Nos

  • Inflammatory Disease Of Mucous Membrane

  • Mucosal Inflammation
Adult-Onset Severe Asthma
Acute Flaccid Myelitis
Bardet-Biedl Syndrome 1

  • BBS1

  • Bardet-Biedl Syndrome 1, Modifier Of

  • Bardet-Biedl Syndrome

  • BBS

  • Bardet-Biedl Syndrome, Type 1

  • Laurence-Moon-Bardet-Biedl Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02345 CDHR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20877 Cdhr3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27394 Cdhr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CDHR3 VGNC VGNC:27110
Mus musculus CDHR3 MGD MGI:1916014
Canis familiaris CDHR3 VGNC VGNC:39039
Rattus norvegicus CDHR3 RGD RGD:1591286
Felis catus CDHR3 VGNC VGNC:69372
Others CDHR3 NCBI