CCT6A - chaperonin containing TCP1 subunit 6A Gene

Also Known as CCT6; Cctz; HTR3; TCPZ; TCP20; MoDP-2; TTCP20; CCT-zeta; CCT-zeta-1; TCP-1-zeta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 908

About CCT6A

Cytogenetic location: 7p11.2 Genomic coordinates (GRCh38): 7:56,051,765-56,063,989 (from NCBI)

This gene has 9 transcripts (splice variants), 122 orthologues and 13 paralogues. Ubiquitous expression in appendix (RPKM 44.1), lymph node (RPKM 38.8) and 25 other tissues.

Summary

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]

CCT6A Products (2)

mRNA Protein Name
NM_001009186.2 NP_001009186.1 T-complex protein 1 subunit zeta isoform b
NM_001762.4 NP_001753.1 T-complex protein 1 subunit zeta isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables WD40-repeat domain binding IPI
IPI: Inferred from physical interaction
25467444 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14532270 GOA
enables protein folding chaperone IDA
IDA: Inferred from direct assay
25467444 GOA
Biological Process GO Annotation Evidence References Source
involved in chaperone mediated protein folding independent of cofactor IMP
IMP: Inferred from mutant phenotype
25467444 GOA
involved in chaperone-mediated protein folding IDA
IDA: Inferred from direct assay
22133715 GOA
acts upstream of positive regulation of establishment of protein localization to telomere IMP
IMP: Inferred from mutant phenotype
25467444 GOA
acts upstream of positive regulation of telomere maintenance via telomerase IMP
IMP: Inferred from mutant phenotype
25467444 GOA
involved in protein folding IDA
IDA: Inferred from direct assay
30955883 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
25467444 GOA
Cellular Component GO Annotation Evidence References Source
part of chaperonin-containing T-complex IDA
IDA: Inferred from direct assay
23011926 GOA
part of chaperonin-containing T-complex IPI
IPI: Inferred from physical interaction
22133715 GOA
located in microtubule IDA
IDA: Inferred from direct assay
21525035 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCT6A Protein Structure

Cpn60_TCP1

Cpn60_TCP1: TCP-1/cpn60 chaperonin family (30 - 524)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 531 a.a.
Protein Preferred Names Protein Names

T-complex protein 1 subunit zeta

  • T-complex protein 1, zeta subunit

CCT6A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CCT6A P40227 TGFBR2 Homo sapiens P37173
Y2H Array
32814053
Intra
CCT6A P40227 TGFBR2 Homo sapiens P37173
Y2H Pooling
32814053
Intra
CCT6A P40227 TGFBR2 Homo sapiens P37173
Validated Y2H
32814053
Intra
CCT6A P40227 CCT8 Homo sapiens P50990
Crosslink
30021884
Intra
CCT6A P40227 CCT8 Homo sapiens P50990
Anti Tag CoIP
35271311
Intra
CCT6A P40227 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
CCT6A P40227 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
CCT6A P40227 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
CCT6A P40227 PRKACA Homo sapiens P17612
Y2H Array
32814053
Intra
CCT6A P40227 PRKACA Homo sapiens P17612
Validated Y2H
32814053
Intra
CCT6A P40227 PRKACA Homo sapiens P17612
Y2H Pooling
32814053
Intra
CCT6A P40227 TRIM31 Homo sapiens Q9BZY9
Validated Y2H
32296183
Intra
CCT6A P40227 TRIM31 Homo sapiens Q9BZY9
Y2H Array
32296183
Intra
CCT6A P40227 TRIM31 Homo sapiens Q9BZY9
Y2H Prey Pooling
32296183
Intra
CCT6A P40227 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra
CCT6A P40227 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra
CCT6A P40227 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra
CCT6A P40227 ATXN3 Homo sapiens P54252
Y2H Array
32814053
Intra
CCT6A P40227 ATXN3 Homo sapiens P54252
Validated Y2H
32814053
Intra
CCT6A P40227 ATXN3 Homo sapiens P54252
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Morphine Dependence
Axillary Adenitis

  • Axillary Lymphadenitis
Short-Rib Thoracic Dysplasia 4 With Or Without Polydactyly

  • Asphyxiating Thoracic Dystrophy 4

  • SRTD4

  • Atd4

  • Jatd

  • Jeune Asphyxiating Thoracic Dystrophy

  • Jeune Syndrome 4
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02183 CCT6A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22422 Cct6a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28945 Cct6a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CCT6A VGNC VGNC:103797
Bos taurus CCT6A VGNC VGNC:97250
Rattus norvegicus CCT6A RGD RGD:1304763
Felis catus CCT6A VGNC VGNC:80556
Canis familiaris CCT6A VGNC VGNC:38926
Mus musculus CCT6A MGD MGI:107943
Others CCT6A NCBI