2. Gene
  3. HTRA4 - HtrA serine peptidase 4 Gene

HTRA4 - HtrA serine peptidase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 203100 | Gene type: protein coding

About HTRA4

Cytogenetic location: 8p11.22 Genomic coordinates (GRCh38): 8:38,974,228-38,988,663 (from NCBI)

This gene has 1 transcript (splice variant), 167 orthologues and 3 paralogues. Biased expression in placenta (RPKM 16.9) and bone marrow (RPKM 1.2).

Summary

This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an Insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this Enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, Apoptosis, and aging. [provided by RefSeq, Oct 2008]

HTRA4 Products(1)

mRNA Protein Name
NM_153692.4 NP_710159.1 serine protease HTRA4 precursor

HTRA4 Protein Structure

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (108 - 152)

Trypsin_2

Trypsin_2: Trypsin-like peptidase domain (202 - 340)

PDZ_2

PDZ_2: PDZ domain (390 - 453)

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  • 476 a.a.
Protein Preferred Names Protein Names

serine protease HTRA4

high-temperature requirement factor A4

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06489 HTRA4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HTRA4 RGD RGD:1306242
Macaca mulatta HTRA4 VGNC VGNC:73447
Mus musculus HTRA4 MGD MGI:3036260
Felis catus HTRA4 VGNC VGNC:62857
Canis familiaris HTRA4 VGNC VGNC:41838
Bos taurus HTRA4 VGNC VGNC:30006