L-Ascorbic acid 2-phosphate magnesium hydrate
Based on 10 publication(s) in Google Scholar
L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) magnesium hydrate is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-ascorbic acid 2-phosphate magnesium hydrate can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate magnesium hydrate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.
For research use only. We do not sell to patients.
- Purity: 99.63%
- CAS No.: 1713265-25-8
- Formula: C6H9O9P.xH2O.3/2Mg
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) L-Ascorbic acid 2-phosphate magnesium hydrate
More- Adv Mater. 2025 Jul 14:e2501306. [Abstract]
- Autophagy. 2023 Feb;19(2):632-643. [Abstract]
- Adv Sci (Weinh). 2025 Nov 21:e08472. [Abstract]
- Adv Sci (Weinh). 2024 Dec;11(46):e2400502. [Abstract]
- Food Hydrocoll. 2026 Mar.
- Int J Biol Macromol. 2025 Dec 12;338(Pt 1):149672. [Abstract]
- Biomolecules. 2025 Nov 19;15(11):1623. [Abstract]
- J Biomed Mater Res A. 2026 Feb;114(2):e70031. [Abstract]
- Cell Transplant. 2025 Jan-Dec:34:9636897251376125. [Abstract]
- Eng Life Sci. 2025 Oct 13;25(10):e70050. [Abstract]
All Endogenous Metabolite Isoforms
More
Biological Activity
L-Ascorbic acid 2-phosphate (0.1-1.5 mM; 2 to 3 weeks with medium exchange every 2 to 3 days) magnesium hydrate significantly stimulates cell growth, whereas addition of l-Ascorbic acid (Asc) achieves only weak growth stimulation. A combination of Asc-2P and bFGF significantly increases cell growth, but supplementation with EGF and/or insulin does not have any additional effect [1]. L-Ascorbic acid 2-phosphate (50 μM-250 μM) magnesium hydrate is needed for the effective osteogenic differentiation of human adipose stem cells (hASCs), and higher concentrations of AsA2-P results in increased runx2 expression and ALP activity. The highest proliferation, ALP activity and runx2 expression is achieved with 150 μM AsA2-P and 10 nM dexamethasone (Dex), and 250 μM AsA2-P and 5 nM Dex[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Human corneal endothelial cells (HCECs)
-
Concentration:0.1 mM; 0.3 mM; 1.5 mM
-
Incubation Time:2 to 3 weeks with medium exchange every 2 to 3 days
-
Result:Stimulated HCEC cells growth.
Chemical Information
-
CAS No. 1713265-25-8
-
Appearance Solid
-
Formula C6H9O9P.xH2O.3/2Mg
-
Color White to off-white
-
SMILES
O=P(O)(O)OC1=C([C@@](OC1=O)([H])[C@@H](O)CO)O.[Mg].O.[x].[3/2]
-
Synonyms
2-Phospho-L-ascorbic acid magnesium hydrate; LAA2P magnesium hydrate
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (10)
-
Journal Impact Factor
-
Most Recent
-
Adv Mater
Piezoelectric Injectable Anti-Adhesive Hydrogel to Promote Endogenous Healing of Tendon Injuries. [Abstract]2025 Jul 14:e2501306. PMID: 40658817 -
Autophagy
Autophagy loss impedes cancer-associated fibroblast activation via downregulating proline biosynthesis. [Abstract]2023 Feb;19(2):632-643. PMID: 35786294 -
Adv Sci (Weinh)
Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression. [Abstract]2025 Nov 21:e08472. PMID: 41268703 -
Adv Sci (Weinh)
Insufficient Mechanical Loading Downregulates Piezo1 in Chondrocytes and Impairs Fracture Healing Through ApoE-Induced Senescence. [Abstract]2024 Dec;11(46):e2400502. PMID: 39418070 -
-
Int J Biol Macromol
Downregulation of the biological macromolecule Spondin-2 disrupts maternal-fetal immune tolerance and trophoblast invasion, driving unexplained recurrent pregnancy loss. [Abstract]2025 Dec 12;338(Pt 1):149672. PMID: 41391791 -
Biomolecules
Mitochondrial Imaging and Transcriptome Analysis of Bone Mesenchymal Stem Cells During Osteogenesis Under Different Culture Conditions. [Abstract]2025 Nov 19;15(11):1623. PMID: 41301543 -
J Biomed Mater Res A
Injectable Butyl Glycidyl Ether-Modified Methylcellulose Thermosensitive Hydrogel for Topical Delivery of Vancomycin Hydrochloride in the Treatment of Osteomyelitis. [Abstract]2026 Feb;114(2):e70031. PMID: 41586469 -
Cell Transplant
Adipose-derived stem cells inhibit dendritic cell migration by secreting tumor necrosis factor-α-stimulated gene 6 to improve the allogeneic skin transplantation survival rate in mice. [Abstract]2025 Jan-Dec:34:9636897251376125. PMID: 41108126 -
Eng Life Sci
Comparative Study of Porcine Mesenchymal Stem Cells Behavior and Lipid Metabolism on Plant-Based Scaffolds and Two-Dimensional Systems for Cultivated Fat. [Abstract]2025 Oct 13;25(10):e70050. PMID: 41098339
Solvent & Solubility
H2O : 18.42 mg/mL (ultrasonic and warming and heat to 60°C)
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
-
Data Sheet (279 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
[1]. Shima N, et al. Increased proliferation and replicative lifespan of isolated human corneal endothelial cells with L-ascorbic acid 2-phosphate.Invest Ophthalmol Vis Sci. 2011 Nov 7;52(12):8711-7. [Content Brief]
[2]. Kurata S, et al. Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative.J Biol Chem. 1991 May 25;266(15):9997-10003. [Content Brief]
[3]. Kyllönen L, et al. Effects of different serum conditions on osteogenic differentiation of human adipose stem cells in vitro.Stem Cell Res Ther. 2013 Feb 15;4(1):17. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz