Cytotoxic steroidal saponins from Ophiopogon japonicus

  • Steroids. 2013 Jan;78(1):1-7. doi: 10.1016/j.steroids.2012.10.001.
Ning Li  1 ,  Liang Zhang ,  Ke-Wu Zeng ,  Yuan Zhou ,  Jia-Yu Zhang ,  Yan-Yun Che ,  Peng-Fei Tu
Affiliations
  • 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, No. 38 Xueyuan Road, Beijing 100191, People's Republic of China.
PMID: 23123739 DOI: 10.1016/j.steroids.2012.10.001
Abstract

Four new steroidal saponins, named ophiopogonin P-S (1-4), together with eleven known ones (5-15) were isolated from the tuberous roots of Ophiopogon japonicus. Their structures were elucidated by spectroscopic and chemical analysis. Compounds 2-15 were evaluated for their cytotoxic activity against five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela). Compounds 2, 5, 6, 8 and 9 were cytotoxic for all cell lines tested. Compounds 7, 11 and 15 showed selective cytotoxicity against some of the cell lines. The structure-activity relationship of these compounds was discussed.

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