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Cat. No.: HY-184445

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Antibacterial agent 355

Antibacterial agent 355 is a bacterial tRNA (m¹G37) methyltransferase (TrmD) inhibitor with an IC₅₀ of 0.85 μM against E. coli. Antibacterial agent 355 shows weak inhibitory activity against human Trm5, with an approximate IC₅₀ of 1.88 mM. Antibacterial agent 355 inhibits the growth of bacterial strains expressing TrmD. Antibacterial agent 355 can be used for the research of bacterial infections.

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Formule: C₂₈H₃₀N₄O₃
Masse moléculaire:470.56

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antibacterial agent 355 Chemical Structure

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Bioz

Activité biologique

Description

In Vitro

Antibacterial agent 355 (Compound 16) (100 μM; 2.5 h) inhibits growth of the hyper-permeable E. coli porin mutant strain by 99.3% at a concentration of 100 μM after 2.5 h of incubation at 37 °C^[1].
Antibacterial agent 355 (16 h) inhibits growth of the hyper-permeable E. coli porin mutant strain with an MIC of 167 μM after 16 h of incubation at 37 °C^[1].
Antibacterial agent 355 (100 μM; 0-8 h) selectively inhibits growth of hyper-permeable bacteria expressing E. coli TrmD, with rapid, near-complete inhibition by 2 h at 100 μM, while showing weaker, slower inhibition of bacteria expressing human Trm5^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 470.56
Formule C₂₈H₃₀N₄O₃
SMILES

O=C(N)C(C=C1)=CN=C1NCC(C)(C)C2=CC(CNC(/C=C/C(C3=CC=C(C)C=C3)=O)=O)=CC=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Masuda, I., et al. (2026). Nicotinamide-Based Covalent Inhibitors of tRNA (m1G37) Methyltransferase (TrmD) to Increase Antibacterial Activity. ACS Medicinal Chemistry Letters.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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