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Cat. No.: HY-170898

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Antidepressant agent 8

Antidepressant agent 8 (Compound 1f) is a selective antagonist for the NMDA receptor GluN1/2A with an IC₅₀ of 2.94 μmol/L. Antidepressant agent 8 exhibits antidepressant-like effects in Hydrocortisone (HY-N0583)-induced zebrafish depression model. Antidepressant agent 8 can cross blood-brain barrier.

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CAS No.: 3066104-04-6
Formule: C₁₈H₂₃FN₄OS₂
Masse moléculaire:394.53

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Antidepressant agent 8 Chemical Structure

CAS No.: 3066104-04-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références
Calculators
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Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

NMDA Receptor

2.94 μg/mL (IC₅₀)

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Chemical Information

CAS No. 3066104-04-6
Masse moléculaire 394.53
Formule C₁₈H₂₃FN₄OS₂
SMILES

FC1=CC(CNC2=NN=C(SCC(NCC3CCCCC3)=O)S2)=CC=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhao F, et al., Discovery of Brain-Penetrative Negative Allosteric Modulators of NMDA Receptors Using FEP-Guided Structure Optimization and Membrane Permeability Prediction. J Chem Inf Model. 2025 Jan 27;65(2):857-872. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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Antidepressant agent 8

Voir tous les produits spécifiques à Isoform iGluR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Antidepressant agent 8 Related Classifications

HY-170898 Related Classifications