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Braxlosiran

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Braxlosiran, one of the components of the AOC Delpacibart braxlosiran (HY-177566), is composed of a siRNA targeting DUX4 (dual homologous box protein) and SMCC linker (HY-42360). Abnormal expression of the DUX4 protein leads to changes in gene expression in muscle cells, and these changes are associated with the loss of muscle function in facioscapulohumeral muscular dystrophy (FSHD).

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  • Pureté: 95.45%
  • Masse moléculaire:13729.26
  • Stockage:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Braxlosiran Chemical Structure
    Braxlosiran Chemical Structure
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609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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  • Braxlosiran Chemical Structure
    Braxlosiran Chemical Structure RNA (Cm-sp-Gm-sp-Am-Cm-Gm-Gm-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)A-Cm-Um-Cm-Gm-Um-Um-Um-Gm-sp-Gm-sp-Am), 5′-[6-[[[4-[(3-mercapto-2,5-dioxo-1-pyrrolidinyl)methyl]cyclohexyl]carbonyl]amino]hexyl hydrogen phosphate], complex with RNA (Um-sp-(2′-deoxy-2′-fluoro)C-sp-Cm-Am-Am-(2′-deoxy-2′-fluoro)A-Cm-Gm-Am-Gm-Um-Cm-Um-(2′-deoxy-2′-fluoro)C-Cm-(2′-deoxy-2′-fluoro)G-Um-Cm-Gm-sp-Um-sp-Um)
    1/16
  • RNA (Cm-sp-Gm-sp-Am-Cm-Gm-Gm-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)A-Cm-Um-Cm-Gm-Um-Um-Um-Gm-sp-Gm-sp-Am), 5′-[6-[[[4-[(3-mercapto-2,5-dioxo-1-pyrrolidinyl)methyl]cyclohexyl]carbonyl]amino]hexyl hydrogen phosphate], complex with RNA (Um-sp-(2′-deoxy-2′-fluoro)C-sp-Cm-Am-Am-(2′-deoxy-2′-fluoro)A-Cm-Gm-Am-Gm-Um-Cm-Um-(2′-deoxy-2′-fluoro)C-Cm-(2′-deoxy-2′-fluoro)G-Um-Cm-Gm-sp-Um-sp-Um)