COX-2-IN-44
COX-2-IN-44 is a potent and orally active COX-2 inhibitor with IC50 values of 0.18,1.14 µM for COX-2, COX-1, respectively. COX-2-IN-44 shows anti-inflammatory activity.
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- Formule: C27H24ClN3O
- Masse moléculaire:441.95
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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COX-2 0.18 μM (IC50) |
COX-1 1.14 μM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Twenty-five adult albino Wistar rats (paw edema)[1]
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Dosage:10 mg/kg
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Administration:P.o.
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Result:Showed anti-inflammatory activity and caused a decrease in paw volume over time and scored a percentage edema of 61.62 %, 54.34 %, and 44.64 % at the 1st, 2nd, and 3rd hour, respectively, decreased the PGE2 plasma level by 42.6 %, reduced the level of IL-1β by 32.0 %.
Chemical Information
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Masse moléculaire 441.95
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Formule C27H24ClN3O
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SMILES
CC(C=C1)=CC=C1NC(C(CC2=CC=C(Cl)C=C2)=C3)=NN=C3/C=C/C4=CC=C(OC)C=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
COX-2-IN-44 Related Classifications
HY-161862 Related Classifications
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