FLT3-IN-22
FLT3-IN-22 (compound 22f) is a potent FLT3 inhibitor with IC50 values of 0.941 nM and 0.199 nM for FLT3 and FLT3/D835Y, respectively. FLT3-IN-22 exhibits strong antiproliferative activity against MV4-11 cells and the mutant FLT kinase expressed Ba/F3 cell lines, including FLT-D835Y and FLT3-F691L.
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- Formule: C24H22N6O2
- Masse moléculaire:426.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 0.941 nM (FLT3) and 0.199 nM (FLT3/D835Y)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | GI50 |
866 nM
Compound: 22f
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Growth inhibition of mouse BaF3 cells measured after 72 hrs by alamar blue cell viability assay
Growth inhibition of mouse BaF3 cells measured after 72 hrs by alamar blue cell viability assay
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[PMID: 37866334] |
Chemical Information
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Masse moléculaire 426.47
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Formule C24H22N6O2
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SMILES
O=C(N[C@H]1CC[C@H](N)C1)C2=CC=C(NN=C3C4=NC5=C(C=C(C6=COC=C6)C=C5)N4)C3=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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