FLT3-IN-24
FLT3-IN-24 (compound 24) is a potent and selective inhibitor of FLT3 kinase with an IC50 of 7.94 nM. FLT3-IN-24 has cell antiproliferative effects.
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- Formule: C23H20N6O2S
- Masse moléculaire:444.51
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>1000 nM
Compound: 24
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Cytotoxicity against HEK293 cells lacking FLT3 activating mutations assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
Cytotoxicity against HEK293 cells lacking FLT3 activating mutations assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
|
[PMID: 38056299] |
| K562 | IC50 |
>1000 nM
Compound: 24
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Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
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[PMID: 38056299] |
| MDA-MB-231 | IC50 |
>1000 nM
Compound: 24
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Antiproliferative activity against human MDA-MB-231 cells lacking FLT3 activating mutations assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
Antiproliferative activity against human MDA-MB-231 cells lacking FLT3 activating mutations assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
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[PMID: 38056299] |
| MOLM-14 | IC50 |
3.16 nM
Compound: 24
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Antiproliferative activity against human MOLM-14 cells harboring FLT3-D835Y mutant assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
Antiproliferative activity against human MOLM-14 cells harboring FLT3-D835Y mutant assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
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[PMID: 38056299] |
| MOLM-14 | IC50 |
4.55 nM
Compound: 24
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Antiproliferative activity against human MOLM-14 cells assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
Antiproliferative activity against human MOLM-14 cells assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
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[PMID: 38056299] |
| MOLM-14 | IC50 |
8.34 nM
Compound: 24
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Antiproliferative activity against human MOLM-14 cells harboring FLT3-F691L mutant assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
Antiproliferative activity against human MOLM-14 cells harboring FLT3-F691L mutant assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
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[PMID: 38056299] |
Chemical Information
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Masse moléculaire 444.51
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Formule C23H20N6O2S
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SMILES
CS(=O)(C1=CC=C(C=C1)NC2=CC=CC(C3=CN=C4C=C(C=CN34)C5=CN(C)N=C5)=N2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FLT3-IN-24 Related Classifications
HY-163068 Related Classifications
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