LBX1 - ladybird homeobox 1 Gene

Also Known as HPX6; CCHS3; HPX-6; LBX1H; homeobox

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10660

About LBX1

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:101,226,994-101,229,463 (from NCBI)

This gene has 1 transcript (splice variant), 253 orthologues, 1 paralogue and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles. [provided by RefSeq, Jul 2008]

LBX1 Products (1)

mRNA	Protein	Name
NM_006562.5	NP_006553.2	transcription factor LBX1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LBX1 Protein Structure

Homeobox

0
100
200
281 a.a.

Protein Preferred Names	Protein Names
transcription factor LBX1	lady bird-like homeobox

LBX1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	LBX1	P52954	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	32296183
Intra	LBX1	P52954	ZNF483	Homo sapiens	Q6P088	Validated Y2H	32296183
Intra	LBX1	P52954	TBCEL	Homo sapiens	Q5QJ74	Validated Y2H	32296183
Intra	LBX1	P52954	KRTAP5-6	Homo sapiens	Q6L8G9	Validated Y2H	32296183
Intra	LBX1	P52954	MAB21L3	Homo sapiens	Q8N8X9	Validated Y2H	32296183
Intra	LBX1	P52954	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	32296183
Intra	LBX1	P52954	WNK3	Homo sapiens	Q9BYP7	Validated Y2H	32296183
Intra	LBX1	P52954	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	LBX1	P52954	PRPF31	Homo sapiens	Q8WWY3	Validated Y2H	32296183
Intra	LBX1	P52954	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	LBX1	P52954	QRICH1	Homo sapiens	Q2TAL8	Validated Y2H	32296183
Intra	LBX1	P52954	EIF5A	Homo sapiens	P63241	Validated Y2H	32296183
Intra	LBX1	P52954	TSSK3	Homo sapiens	Q96PN8	Validated Y2H	32296183
Intra	LBX1	P52954	AIPL1	Homo sapiens	Q9NZN9	Validated Y2H	32296183
Intra	LBX1	P52954	TMEM252	Homo sapiens	Q8N6L7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Central Hypoventilation Syndrome, Congenital, 3	CCHS3 Hypoventilation, Central, Syndrome, Congenital, Type 3
Congenital Central Hypoventilation Syndrome	Cchs Haddad Syndrome Ondine Curse Ondine Syndrome Congenital Central Hypoventilation Congenital Central Alveolar Hypoventilation Syndrome Congenital Failure Of Autonomic Control Ondine'S Curse Primary Alveolar Hypoventilation Ondine-Hirschsprung Disease Central Congenital Hypoventilation Syndrome Congenital Ondine Curse Idiopathic Congenital Central Alveolar Hypoventilation Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome Ondine-Hirschsprung Syndrome
Split-Hand/Foot Malformation 3	SHFM3 Split Hand-Foot Malformation 3 Chromosome 10q24 Duplication Syndrome Shsf3 Limb Deficiencies, Distal, With Micrognathia Split-Hand/Foot Malformation 3, Gene Duplication Syndrome Distal Limb Deficiencies With Micrognathia Limb Deficiencies Distal With Micrognathia Buttiens Fryns Syndrome Distal Limb Deficiencies-Micrognathia Syndrome 10q24 Microduplication Syndrome Buttiens-Fryns Syndrome Split-Hand/Foot Malformation, Type 3, Gene Duplication Syndrome
Scoliosis
Idiopathic Scoliosis	Scoliosis Idiopathic
Split-Hand/Foot Malformation 4	SHFM4 Split Hand-Foot Malformation 4 Split-Hand/Foot Malformation, Type 4
Split Hand-Foot Malformation	Ectrodactyly Split-Hand/Foot Malformation Lobster-Claw Deformity Split-Hand Deformity Split Hand Foot Malformation Shfm Split Hand Foot Deformity Split Hand Foot Deformity 1
Bone Structure Disease
Central Sleep Apnea	Central Sleep Apnea Syndrome Sleep Apnea, Central Primary Central Sleep Apnea Central Sleep Apnea, Primary Central Sleep Apnoea Syndrome Csa - [Central Sleep Apnoea] Csas - [Central Sleep Apnoea Syndrome] Central Sleep Apnoea Due To Substances Including Medications
Brachydactyly, Type A2	Brachydactyly Type A2 BDA2 Mohr-Wriedt Type Brachydactyly Brachymesophalangy Ii Brachymesophalangy Type 2 Brachymesophalangy 2 Brachydactyly, Mohr-Wriedt Type Brachydactyly A2
Hypotonia-Cystinuria Syndrome	Cystinuria With Mitochondrial Disease 2p21 Microdeletion Syndrome HCS Homozygous 2p16 Deletion Syndrome, Formerly 2p21 Deletion Syndrome Del(2)(P21) Monosomy 2p21 Atypical Hypotonia-Cystinuria Syndrome Atypical Hcs
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS07546	LBX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LBX1	MGD	MGI:104867
Macaca mulatta	LBX1	VGNC	VGNC:106066
Rattus norvegicus	LBX1	RGD	RGD:1564197
Bos taurus	LBX1	VGNC	VGNC:30805
Canis familiaris	LBX1	VGNC	VGNC:42603
Others	LBX1	NCBI