WNK3 - WNK lysine deficient protein kinase 3 Gene

Also Known as PRKWNK3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 65267

About WNK3

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:54,192,823-54,358,900 (from NCBI)

This gene has 4 transcripts (splice variants), 217 orthologues and 6 paralogues. Biased expression in testis (RPKM 7.2), brain (RPKM 1.1) and 5 other tissues.

Summary

This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

WNK3 Products (3)

mRNA	Protein	Name
NM_001002838.4	NP_001002838.1	serine/threonine-protein kinase WNK3 isoform 2
NM_001395166.1	NP_001382095.1	serine/threonine-protein kinase WNK3 isoform 2
NM_020922.5	NP_065973.2	serine/threonine-protein kinase WNK3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	36318922	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16501604	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	16275913	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	17975670	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell volume homeostasis	IDA IDA: Inferred from direct assay	36318922	GOA
acts upstream of cell volume homeostasis	IMP IMP: Inferred from mutant phenotype	27782176	GOA
involved in cellular hyperosmotic response	IDA IDA: Inferred from direct assay	36318922	GOA
involved in monoatomic ion homeostasis	IMP IMP: Inferred from mutant phenotype	21613606	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16501604	GOA
involved in negative regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	17673510	GOA
involved in non-membrane-bounded organelle assembly	IDA IDA: Inferred from direct assay	36318922	GOA
acts upstream of osmosensory signaling pathway	IMP IMP: Inferred from mutant phenotype	27782176	GOA
involved in positive regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	18768590	GOA
involved in positive regulation of ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	16275913	GOA
involved in positive regulation of peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	16275913	GOA
involved in positive regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	16275913	GOA
involved in positive regulation of sodium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	16275913	GOA
involved in positive regulation of sodium ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	21613606	GOA
involved in positive regulation of sodium ion transport	IDA IDA: Inferred from direct assay	16275913	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	16275913	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	18768590	GOA
involved in regulation of calcium ion import	IMP IMP: Inferred from mutant phenotype	18768590	GOA
acts upstream of regulation of monoatomic cation transmembrane transport	IMP IMP: Inferred from mutant phenotype	27782176	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16501604	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WNK3 Protein Structure

Pkinase

OSR1_C

0
300
600
900
1200
1500
1800 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase WNK3	protein kinase with no lysine 3

WNK3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WNK3	Q9BYP7	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	WNK3	Q9BYP7	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	WNK3	Q9BYP7	LBX1	Homo sapiens	P52954	Y2H Prey Pooling	32296183
Intra	WNK3	Q9BYP7	LBX1	Homo sapiens	P52954	Y2H Array	32296183
Intra	WNK3	Q9BYP7	CASP3	Homo sapiens	P42574	Anti Bait CoIP	16501604

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Prieto Syndrome	Prieto-Badia-Mulas Syndrome X-Linked Intellectual Disability-Dysmorphism-Cerebral Atrophy Syndrome PRS Mrxs2 Prieto X-Linked Mental Retardation Syndrome Mental Retardation, X-Linked, Syndromic 2 Mental Retardation, X-Linked, With Dysmorphism And Cerebral Atrophy Intellectual Disability, X-Linked, Syndromic 2
Hypomagnesemia 4, Renal	Renal Hypomagnesemia 4 HOMG4 Hypomagnesemia, Renal, Normocalciuric Hypomagnesemia 4 Renal Hypomagnesemia Normocalciuric Hypomagnesemia, Type 4, Renal
Arthrogryposis, Distal, Type 3	Gordon Syndrome DA3 Distal Arthrogryposis Type 3 Arthrogryposis Multiplex Congenita, Distal, Type Iia Camptodactyly, Cleft Palate, And Clubfoot Camptodactyly-Cleft Palate-Clubfoot Syndrome Distal Arthrogryposis Multiplex Congenita Type Iia Arthrogryposis Distal Type 3 Distal Arthrogryposis Type Iia Arthrogryposis, Distal, 3 Pseudohypoaldosteronism, Type Ii
Agenesis Of The Corpus Callosum With Peripheral Neuropathy	Andermann Syndrome Charlevoix Disease ACCPN Polyneuropathy, Sensorimotor, With Or Without Agenesis Of The Corpus Callosum Corpus Callosum, Agenesis Of, With Neuronopathy Corpus Callosum Agenesis-Neuronopathy Syndrome Agenesis Of Corpus Callosum With Neuronopathy Agenesis Of Corpus Callosum With Peripheral Neuropathy Agenesis Of Corpus Callosum With Polyneuropathy Corpus Callosum Agenesis Neuronopathy Hmsn/Acc Hereditary Motor And Sensory Neuropathy With Agenesis Of The Corpus Callosum Agenesis Of The Corpus Callosum, With Peripheral Neuropathy Andermann'S Syndrome Agenesis, Corpus Callosum, With Peripheral Neuropathy
Pseudohypoaldosteronism
Syndromic X-Linked Intellectual Disability Siderius Type	Mrxssd Siderius-Hamel Syndrome Siderius X-Linked Mental Retardation Syndrome
Gitelman Syndrome	Familial Hypokalemia-Hypomagnesemia Hypomagnesemia-Hypokalemia, Primary Renotubular, With Hypocalciuria Potassium And Magnesium Depletion GTLMNS Gitelman'S Syndrome Gs Hypokalemia-Hypomagnesemia, Primary Renotubular, With Hypocalciuria Tubular Hypomagnesemia-Hypokalemia With Hypocalcuria Bartter Syndrome Gitelman Variant Bartter Syndrome Hypocalciuric Variant Primary Renotubular Hypomagnesemia-Hypokalemia With Hypocalciuria
Bartter Disease	Bartter Syndrome Bartter'S Syndrome Aldosteronism With Hyperplasia Of The Adrenal Cortex Hypokalemic Alkalosis With Hypercalciuria Potassium Wasting Juxtaglomerular Hyperplasia With Secondary Aldosteronism Renal Tubular Normotensive Hypokalemic Alkalosis With Hypercalciuria Salt-Losing Tubular Disorder, Henle'S Loop Type Salt-Wasting Tubulopathy, Henle'S Loop Type Bartters Syndrome
Renal Tubular Transport Disease	Renal Tubular Transport, Inborn Errors Inborn Renal Tubular Transport Disorder
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100626	WNK463	Inhibitor	99.75%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	WNK3	MGD	MGI:2652875
Macaca mulatta	WNK3	VGNC	VGNC:78962
Rattus norvegicus	WNK3	RGD	RGD:1563131
Bos taurus	WNK3	VGNC	VGNC:36951
Felis catus	WNK3	VGNC	VGNC:67078
Others	WNK3	NCBI