Ppl - periplakin Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19041

Summary

Predicted to enable structural molecule activity. Predicted to be involved in intermediate filament Cytoskeleton organization and wound healing. Predicted to act upstream of or within keratinization. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; lower urinary tract; naris; skin; and trachea. Orthologous to human PPL (periplakin). [provided by Alliance of Genome Resources, Apr 2022]

Ppl Products (1)

mRNA Protein Name
NM_008909.2 NP_032935.2 periplakin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
12244133 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within regulation of antibacterial peptide production IGI
IGI: Inferred from genetic interaction
27427436 MGI
Cellular Component GO Annotation Evidence Références Source
is active in cornified envelope IDA
IDA: Inferred from direct assay
26644517 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
19029034 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
19029034 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

periplakin

  • 195kDa protein

Ppl Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Cross
Ppl Q9R269 AKT1 Bos taurus Q01314
Y2H
12244133
Cross
Ppl Q9R269 AKT1 Bos taurus Q01314
Pull Down
12244133
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-107098 PPL-100 free acid / Unkown
HY-159917 PPL agonist-1 / Unkown
HY-RS10959 PPL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18900 Ppl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25391 Ppl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppl NCBI NCBI:5493