KDM1B - lysine demethylase 1B Gene

Also Known as AOF1; LSD2; C6orf193

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 221656

About KDM1B

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:18,155,422-18,223,854 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 7 paralogues. Broad expression in thyroid (RPKM 17.9), testis (RPKM 11.6) and 23 other tissues.

Summary

Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic MARK that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009]

KDM1B Products (2)

mRNA Protein Name
NM_001364614.2 NP_001351543.1 lysine-specific histone demethylase 2 1
NM_153042.4 NP_694587.3 lysine-specific histone demethylase 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables FAD binding IDA
IDA: Inferred from direct assay
23260659 GOA
enables FAD-dependent H3K4me/H3K4me3 demethylase activity IDA
IDA: Inferred from direct assay
23260659 GOA
enables histone binding IDA
IDA: Inferred from direct assay
23260659 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23260659 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
23260659 GOA
Biological Process GO Annotation Evidence Références Source
involved in transcription initiation-coupled chromatin remodeling IDA
IDA: Inferred from direct assay
30970244 GOA
Cellular Component GO Annotation Evidence Références Source
located in chromatin IDA
IDA: Inferred from direct assay
30970244 GOA
part of nucleosome IDA
IDA: Inferred from direct assay
23260659 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KDM1B Protein Structure

zf-CW

zf-CW: CW-type Zinc Finger (137 - 192)

Thi4

Thi4: Thi4 family (247 - 300)

Amino_oxidase

Amino_oxidase: Flavin containing amine oxidoreductase (319 - 587)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 590 a.a.
Protein Preferred Names Protein Names

lysine-specific histone demethylase 2

lysine-specific histone demethylase 1B

  • flavin-containing amine oxidase domain-containing protein 1

KDM1B Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P83638 KDM1B Antibody (YA3383) WB, ICC/IF, FC, IP Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS07208 KDM1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21615 Kdm1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28133 Kdm1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus KDM1B VGNC VGNC:63068
Bos taurus KDM1B VGNC VGNC:30523
Macaca mulatta KDM1B VGNC VGNC:73878
Canis familiaris KDM1B VGNC VGNC:42319
Mus musculus KDM1B MGD MGI:2145261
Rattus norvegicus KDM1B RGD RGD:1310701
Others KDM1B NCBI