ERP44 - endoplasmic reticulum protein 44 Gene

Also Known as PDIA10; TXNDC4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23071

About ERP44

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:99,979,185-100,099,000 (from NCBI)

This gene has 15 transcripts (splice variants), 208 orthologues and 13 paralogues. Ubiquitous expression in thyroid (RPKM 19.6), placenta (RPKM 16.9) and 25 other tissues.

Summary

This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. This protein functions as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface. [provided by RefSeq, Dec 2016]

ERP44 Products (1)

mRNA	Protein	Name
NM_015051.3	NP_055866.1	endoplasmic reticulum resident protein 44 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17805346	GOA
enables protein disulfide isomerase activity	IDA IDA: Inferred from direct assay	11847130	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in glycoprotein metabolic process	IDA IDA: Inferred from direct assay	11847130	GOA
involved in protein folding	IDA IDA: Inferred from direct assay	11847130	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	11847130	GOA
involved in response to unfolded protein	IDA IDA: Inferred from direct assay	11847130	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cell surface	IDA IDA: Inferred from direct assay	19995400	GOA
located in endoplasmic reticulum lumen	IDA IDA: Inferred from direct assay	11847130	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	11847130	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	15308636	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERP44 Protein Structure

Thioredoxin

Thioredoxin_6

0
100
200
300
406 a.a.

Protein Preferred Names	Protein Names
endoplasmic reticulum resident protein 44	ER protein 44

ERP44 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	ERP44	Q9BS26	LMAN1	Homo sapiens	P49257	IF	17805346
Intra	ERP44	Q9BS26	LYN	Homo sapiens	P07948	Validated Y2H	32814053
Intra	ERP44	Q9BS26	LYN	Homo sapiens	P07948	Y2H Array	32814053
Intra	ERP44	Q9BS26	LYN	Homo sapiens	P07948	Y2H Pooling	32814053
Intra	ERP44	Q9BS26	CSNK1D	Homo sapiens	P48730-2	Validated Y2H	32814053
Intra	ERP44	Q9BS26	CSNK1D	Homo sapiens	P48730-2	Y2H Array	32814053
Intra	ERP44	Q9BS26	CSNK1D	Homo sapiens	P48730-2	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ERP44 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P70901	TXNDC4 Protein, Human (HEK293, His)	Q9BS26 (E30-D402)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Multiple Sulfatase Deficiency	Mucosulfatidosis MSD Sulfatidosis, Juvenile, Austin Type Multiple Sulfatase Deficiency Disease Juvenile Sulfatidosis, Austin Type Juvenile Sulfatidosis Sulfatidosis Juvenile, Austin Type Austin Syndrome Sulfatidosis Juvenile Austin Type Sulfatase Deficiency, Multiple

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS04515	ERP44 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ERP44	MGD	MGI:1923549
Macaca mulatta	ERP44	VGNC	VGNC:72295
Bos taurus	ERP44	VGNC	VGNC:28597
Felis catus	ERP44	VGNC	VGNC:61957
Canis familiaris	ERP44	VGNC	VGNC:51716
Rattus norvegicus	ERP44	RGD	RGD:1309176
Others	ERP44	NCBI