MYRIP - myosin VIIA and Rab interacting protein Gene

Also Known as SLAC2C; SLAC2-C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25924

About MYRIP

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:39,808,914-40,260,321 (from NCBI)

This gene has 10 transcripts (splice variants), 116 orthologues and 2 paralogues. Broad expression in brain (RPKM 7.4), spleen (RPKM 4.2) and 23 other tissues.

Summary

Predicted to enable actin binding activity and Myosin binding activity. Predicted to be involved in positive regulation of Insulin secretion. Predicted to be located in actin cytoskeleton; dense core granule; and perinuclear region of cytoplasm. Predicted to be part of exocyst. Predicted to be active in cortical actin Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

MYRIP Products (5)

mRNA Protein Name
NM_001284423.2 NP_001271352.1 rab effector MyRIP isoform a
NM_001284424.2 NP_001271353.1 rab effector MyRIP isoform b
NM_001284425.2 NP_001271354.1 rab effector MyRIP isoform c
NM_001284426.2 NP_001271355.1 rab effector MyRIP isoform d
NM_015460.4 NP_056275.2 rab effector MyRIP isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
11964381 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYRIP Protein Structure

FYVE_2

FYVE_2: FYVE-type zinc finger (9 - 125)

Rab_eff_C

Rab_eff_C: Rab effector MyRIP/melanophilin C-terminus (152 - 859)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 859 a.a.
Protein Preferred Names Protein Names

rab effector MyRIP

  • Slp homologue lacking C2 domains

MYRIP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
MYRIP Q8NFW9 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra
MYRIP Q8NFW9 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra
MYRIP Q8NFW9 C1orf216 Homo sapiens Q8TAB5
Validated Y2H
32296183
Intra
MYRIP Q8NFW9 C1orf216 Homo sapiens Q8TAB5
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Deafness, Autosomal Dominant 50

  • DFNA50

  • Autosomal Dominant Nonsyndromic Deafness 50

  • Autosomal Dominant Deafness 50

  • Deafness, Autosomal Dominant, Type 50
Griscelli Syndrome

  • Chediak-Higashi-Like Syndrome

  • Griscelli-Prunieras Syndrome

  • Partial Albinism-Immunodeficiency Syndrome

  • Griscelli Disease

  • Gs

  • Hypopigmentation Immunodeficiency Disease

  • Partial Albinism With Immunodeficiency

  • Immunodeficiency Syndrome With Hypopigmentation

  • Hypopigmentation-Immunodeficiency Disease
Cerebrooculofacioskeletal Syndrome 1

  • Cofs Syndrome

  • COFS1

  • Pena-Shokeir Syndrome Type 2

  • Cofs

  • Pena-Shokeir Syndrome, Type Ii

  • Cerebrooculofacioskeletal Syndrome

  • Cerebro-Oculo-Facio-Skeletal Syndrome 1

  • Pena Shokeir Syndrome Type 2
Usher Syndrome

  • Deafness-Retinitis Pigmentosa Syndrome

  • Dystrophia Retinae Pigmentosa-Dysostosis Syndrome

  • Graefe-Usher Syndrome

  • Hallgren Syndrome

  • Usher'S Syndrome

  • Retinitis Pigmentosa-Deafness Syndrome

  • Retinitis Pigmentosa-Hearing Loss Syndrome

  • Ush

  • Usher Syndromes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS08971 MYRIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MYRIP MGD MGI:2384407
Felis catus MYRIP VGNC VGNC:102783
Bos taurus MYRIP VGNC VGNC:31846
Macaca mulatta MYRIP VGNC VGNC:74992
Rattus norvegicus MYRIP RGD RGD:727731
Canis familiaris MYRIP VGNC VGNC:43589
Others MYRIP NCBI