country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

MYRIP - myosin VIIA and Rab interacting protein Gene

Also Known as SLAC2C; SLAC2-C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25924

About MYRIP

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:39,808,914-40,260,321 (from NCBI)

This gene has 10 transcripts (splice variants), 116 orthologues and 2 paralogues. Broad expression in brain (RPKM 7.4), spleen (RPKM 4.2) and 23 other tissues.

Summary

Predicted to enable actin binding activity and Myosin binding activity. Predicted to be involved in positive regulation of Insulin secretion. Predicted to be located in actin cytoskeleton; dense core granule; and perinuclear region of cytoplasm. Predicted to be part of exocyst. Predicted to be active in cortical actin Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

MYRIP Products (5)

mRNA	Protein	Name
NM_001284423.2	NP_001271352.1	rab effector MyRIP isoform a
NM_001284424.2	NP_001271353.1	rab effector MyRIP isoform b
NM_001284425.2	NP_001271354.1	rab effector MyRIP isoform c
NM_001284426.2	NP_001271355.1	rab effector MyRIP isoform d
NM_015460.4	NP_056275.2	rab effector MyRIP isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11964381	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYRIP Protein Structure

FYVE_2

Rab_eff_C

0
200
400
600
800
859 a.a.

Protein Preferred Names	Protein Names
rab effector MyRIP	Slp homologue lacking C2 domains

MYRIP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MYRIP	Q8NFW9	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	MYRIP	Q8NFW9	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	MYRIP	Q8NFW9	C1orf216	Homo sapiens	Q8TAB5	Validated Y2H	32296183
Intra	MYRIP	Q8NFW9	C1orf216	Homo sapiens	Q8TAB5	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Deafness, Autosomal Dominant 50	DFNA50 Autosomal Dominant Nonsyndromic Deafness 50 Autosomal Dominant Deafness 50 Deafness, Autosomal Dominant, Type 50
Griscelli Syndrome	Chediak-Higashi-Like Syndrome Griscelli-Prunieras Syndrome Partial Albinism-Immunodeficiency Syndrome Griscelli Disease Gs Hypopigmentation Immunodeficiency Disease Partial Albinism With Immunodeficiency Immunodeficiency Syndrome With Hypopigmentation Hypopigmentation-Immunodeficiency Disease
Cerebrooculofacioskeletal Syndrome 1	Cofs Syndrome COFS1 Pena-Shokeir Syndrome Type 2 Cofs Pena-Shokeir Syndrome, Type Ii Cerebrooculofacioskeletal Syndrome Cerebro-Oculo-Facio-Skeletal Syndrome 1 Pena Shokeir Syndrome Type 2
Usher Syndrome	Deafness-Retinitis Pigmentosa Syndrome Dystrophia Retinae Pigmentosa-Dysostosis Syndrome Graefe-Usher Syndrome Hallgren Syndrome Usher'S Syndrome Retinitis Pigmentosa-Deafness Syndrome Retinitis Pigmentosa-Hearing Loss Syndrome Ush Usher Syndromes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08971	MYRIP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MYRIP	MGD	MGI:2384407
Felis catus	MYRIP	VGNC	VGNC:102783
Bos taurus	MYRIP	VGNC	VGNC:31846
Macaca mulatta	MYRIP	VGNC	VGNC:74992
Rattus norvegicus	MYRIP	RGD	RGD:727731
Canis familiaris	MYRIP	VGNC	VGNC:43589
Others	MYRIP	NCBI