SERPINA5 - serpin family A member 5 Gene

Also Known as PCI; PAI3; PAI-3; PCI-B; PROCI; PLANH3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5104

About SERPINA5

Cytogenetic location: 14q32.13 Genomic coordinates (GRCh38): 14:94,581,426-94,593,118 (from NCBI)

This gene has 12 transcripts (splice variants), 86 orthologues and 36 paralogues. Biased expression in testis (RPKM 322.5), adrenal (RPKM 213.7) and 6 other tissues.

Summary

The protein encoded by this gene is a member of the Serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of Serpin genes located on the q arm of chromosome 14. This family member is a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. [provided by RefSeq, Aug 2012]

SERPINA5 Products (1)

mRNA Protein Name
NM_000624.6 NP_000615.3 plasma serine protease inhibitor preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables acrosin binding IPI
IPI: Inferred from physical interaction
7521127 GOA
enables phosphatidylcholine binding IDA
IDA: Inferred from direct assay
9556620 GOA
enables protease binding IPI
IPI: Inferred from physical interaction
1725227 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7521127 GOA
enables retinoic acid binding IDA
IDA: Inferred from direct assay
11722589 GOA
enables serine-type endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
1725227 GOA
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of hydrolase activity IMP
IMP: Inferred from mutant phenotype
8665956 GOA
Cellular Component GO Annotation Evidence Références Source
located in acrosomal membrane IDA
IDA: Inferred from direct assay
7521127 GOA
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
9556620 GOA
located in extracellular exosome IDA
IDA: Inferred from direct assay
21557262 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
1725227 GOA
located in membrane IDA
IDA: Inferred from direct assay
7521127 GOA
located in platelet alpha granule IDA
IDA: Inferred from direct assay
9556620 GOA
located in platelet dense tubular network IDA
IDA: Inferred from direct assay
9556620 GOA
part of protein C inhibitor-KLK3 complex IDA
IDA: Inferred from direct assay
1725227 GOA
part of protein C inhibitor-PLAT complex IDA
IDA: Inferred from direct assay
10340997 GOA
part of protein C inhibitor-PLAU complex IDA
IDA: Inferred from direct assay
3501295 GOA
part of protein C inhibitor-TMPRSS11E complex IDA
IDA: Inferred from direct assay
15328353 GOA
part of protein C inhibitor-TMPRSS7 complex IDA
IDA: Inferred from direct assay
15853774 GOA
part of protein C inhibitor-coagulation factor V complex IDA
IDA: Inferred from direct assay
6323392 GOA
part of protein C inhibitor-coagulation factor XI complex IDA
IDA: Inferred from direct assay
2844223 GOA
part of protein C inhibitor-coagulation factor Xa complex IDA
IDA: Inferred from direct assay
6323392 GOA
part of protein C inhibitor-plasma kallikrein complex IDA
IDA: Inferred from direct assay
2844223 GOA
part of protein C inhibitor-thrombin complex IDA
IDA: Inferred from direct assay
6323392 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
7521127 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERPINA5 Protein Structure

Serpin

Serpin: Serpin (serine protease inhibitor) (45 - 406)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
Protein Preferred Names Protein Names

plasma serine protease inhibitor

  • acrosomal serine protease inhibitor

Recombinant SERPINA5 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P70975 Serpin A5 Protein, Human (HEK293, His) AAH08915.1 (H20-P406) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Pontocerebellar Hypoplasia, Type 14

  • PCH14

  • Pontocerebellar Hypoplasia Type 14

  • Pontocerebellar Hypoplasia 14

  • Doid:0112325
Thrombosis

  • Thrombosis Of Blood Vessel
Epilepsy, Idiopathic Generalized 13

  • Epilepsy, Childhood Absence 4

  • EIG13

  • Epilepsy, Idiopathic Generalized, Susceptibility To, 13

  • Epilepsy, Childhood Absence, Susceptibility To, 4

  • Idiopathic Generalized Epilepsy 13

  • Epilepsy, Juvenile Myoclonic, Susceptibility To, 5

  • Epilepsy, Juvenile Myoclonic 5

  • ECA4

  • Juvenile Myoclonic Epilepsy 5

  • EJM5

  • Susceptibility To Juvenile Myoclonic Epilepsy 5

  • Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 13
Spherocytosis, Type 5

  • Hereditary Spherocytosis Type 5

  • SPH5

  • Hs5

  • Spherocytosis, Hereditary, 5

  • Hereditary Spherocytosis 5

  • Spherocytosis 5

  • Spherocytosis, Hereditary, Type 5
Varicocele

  • Scrotal Varices

  • Varicoceles

  • Varicocele Of Scrotum

  • Scrotal Varicocele
Malignant Ovarian Cyst
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS12701 SERPINA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18211 Serpina5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24688 Serpina5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SERPINA5 MGD MGI:107817
Bos taurus SERPINA5 VGNC VGNC:53954
Macaca mulatta SERPINA5 VGNC VGNC:77364
Felis catus SERPINA5 VGNC VGNC:68725
Rattus norvegicus SERPINA5 RGD RGD:619817
Canis familiaris SERPINA5 VGNC VGNC:103705
Others SERPINA5 NCBI